RISK POLYMORPHISMS IN ORAL LEUKOPLAKIA: A SYSTEMATIC REVIEW
Fil: Bono, Alejandra, Liliana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Periodoncia A; Argentina.
| Main Authors: | , , , , |
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| Format: | conferenceObject |
| Language: | eng |
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2025
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| Online Access: | http://hdl.handle.net/11086/556844 |
| _version_ | 1839749085867802624 |
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| author | Bono, Alejandra Zárate, Ana María Don, Julieta Barra, José Luis Brunotto, Mabel |
| author_facet | Bono, Alejandra Zárate, Ana María Don, Julieta Barra, José Luis Brunotto, Mabel |
| author_sort | Bono, Alejandra |
| collection | Repositorio Digital Universitario |
| description | Fil: Bono, Alejandra, Liliana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Periodoncia A; Argentina. |
| format | conferenceObject |
| id | rdu-unc.556844 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2025 |
| record_format | dspace |
| spelling | rdu-unc.5568442025-08-05T15:27:28Z RISK POLYMORPHISMS IN ORAL LEUKOPLAKIA: A SYSTEMATIC REVIEW Bono, Alejandra Zárate, Ana María Don, Julieta Barra, José Luis Brunotto, Mabel Systematic review Oral leukoplakia Fil: Bono, Alejandra, Liliana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Periodoncia A; Argentina. Fil: Zárate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. Fil: Don, Julieta. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina. Fil: Barra, José Luis . Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento Química Biológica; Argentina. Fil: Barra, José Luis . Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica; Argentina. Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. Introduction The greatest challenge is to predict which oral leukoplakia (OL) will be able to progress to oral squamous cell carcinoma. Purpose Generally, the systematic reviews and meta-analysis of polymorphisms are focused in genes related to unique cellular process; in this work, our goal was to identify studied genes in last decade and to know which ones are related to the risk of developing OL. Method Eligible gene/polymorphism studies were identified by electronic searches. Individual participant data of 2054 Oral Leukoplakia and 3493 controls from 16 genetic studies were analyzed, yielding adjusted (tobacco, gender, age and alcohol) odds ratios (OR) and 95% confidence intervals (CIs) comparing cases with controls. Results The following genes/polymorphisms were seen to have significant association with increased risk of OL: CYPA1 (m1/m2), XDP (Gln/Gln), GSTM1 (null), and P53 (intron 6). In contrast, COX-2 (exon 10), P53 (intron 3), XRCC3 (GG), and PRKDC (rs7003908) polymorphisms are associated with a diminished risk of OL. Conclusions According to the results of this work, we conclude that all genotypes are heterozygous or homozygous for the polymorphic variants; and the people with genotypes CYP1A1 m1/m2, XDP Gln/Gln, GSTM1 null, P53 intron 6, XRCC3 rs861539, COX2 -765 have high risk of presented OL, and therefore they are more exposed to oral cancer risk. http://www.journals.elsevier.com/oral-oncology/ Fil: Bono, Alejandra, Liliana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Periodoncia A; Argentina. Fil: Zárate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. Fil: Don, Julieta. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina. Fil: Barra, José Luis . Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento Química Biológica; Argentina. Fil: Barra, José Luis . Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica; Argentina. Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. Epidemiología 2025-08-05T13:37:15Z 2025-08-05T13:37:15Z 2015 conferenceObject 1368-8375 http://hdl.handle.net/11086/556844 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Electrónico y/o Digital |
| spellingShingle | Systematic review Oral leukoplakia Bono, Alejandra Zárate, Ana María Don, Julieta Barra, José Luis Brunotto, Mabel RISK POLYMORPHISMS IN ORAL LEUKOPLAKIA: A SYSTEMATIC REVIEW |
| title | RISK POLYMORPHISMS IN ORAL LEUKOPLAKIA: A SYSTEMATIC REVIEW |
| title_full | RISK POLYMORPHISMS IN ORAL LEUKOPLAKIA: A SYSTEMATIC REVIEW |
| title_fullStr | RISK POLYMORPHISMS IN ORAL LEUKOPLAKIA: A SYSTEMATIC REVIEW |
| title_full_unstemmed | RISK POLYMORPHISMS IN ORAL LEUKOPLAKIA: A SYSTEMATIC REVIEW |
| title_short | RISK POLYMORPHISMS IN ORAL LEUKOPLAKIA: A SYSTEMATIC REVIEW |
| title_sort | risk polymorphisms in oral leukoplakia a systematic review |
| topic | Systematic review Oral leukoplakia |
| url | http://hdl.handle.net/11086/556844 |
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