Allele and genotype frequencies of metabolic genes in Native Americans from Argentina and Paraguay

Interethnic differences in the allele frequencies of CYP2D6, NAT2, GSTM1 and GSTT1 deletions have been documented for Caucasians, Asians, and Africans population. On the other hand, data on Amerindians are scanty and limited to a few populations from southern areas of South America. In this report w...

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Main Authors: Bailliet, Graciela, Santos, María Rita, Alfaro, E. L., Dipierri, J. E., Demarchi, Dario, Carnese, F. R., Bianchi, Nestor
Format: info:eu-repo/semantics/article
Language:eng
Published: Elsevier Science 2007
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Online Access:http://hdl.handle.net/11336/237358
https://suquia.ffyh.unc.edu.ar/handle/suquia/174919
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author Bailliet, Graciela
Santos, María Rita
Alfaro, E. L.
Dipierri, J. E.
Demarchi, Dario
Carnese, F. R.
Bianchi, Nestor
author_facet Bailliet, Graciela
Santos, María Rita
Alfaro, E. L.
Dipierri, J. E.
Demarchi, Dario
Carnese, F. R.
Bianchi, Nestor
author_sort Bailliet, Graciela
collection Repositorio Suquia
description Interethnic differences in the allele frequencies of CYP2D6, NAT2, GSTM1 and GSTT1 deletions have been documented for Caucasians, Asians, and Africans population. On the other hand, data on Amerindians are scanty and limited to a few populations from southern areas of South America. In this report we analyze the frequencies of 11 allele variants of CYP2D6 and 4 allele variants of NAT2 genes, and the frequency of GSTM1 and GSTT1 homozygous deleted genotypes in a sample of 90 donors representing 8 Native American populations from Argentina and Paraguay, identified as Amerindians on the basis of their geographic location, genealogical data, mitochondrial- andY-chromosomeDNAmarkers. For CYP2D6, 88.6% of the total allele frequency corresponded to *1, *2, *4 and *10 variants. Average frequencies for NAT2 *4, *5, *6 and *7 alleles were 51.2%, 25%, 6.1%, and 20.1%, respectively. GSTM1 deletion ranged from 20% to 66%, while GSTT1 deletion was present in four populations in less than 50%.We assume that CYP2D6 *2, *4, *10, *14; NAT2 *5, *7 alleles and GSTM1 and GSTT1 *0/*0 genotypes are founder variants brought to America by the first Asian settlers.
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spelling suquia-ffyh.1749192024-08-02T01:21:38Z Allele and genotype frequencies of metabolic genes in Native Americans from Argentina and Paraguay Bailliet, Graciela Santos, María Rita Alfaro, E. L. Dipierri, J. E. Demarchi, Dario Carnese, F. R. Bianchi, Nestor CYP2D6 N-Acetyltransferase 2 Human Glutathione S-transferase M1 GST theta 1 American Native Continental Ancestry Group https://purl.org/becyt/ford/5.4 https://purl.org/becyt/ford/5 Interethnic differences in the allele frequencies of CYP2D6, NAT2, GSTM1 and GSTT1 deletions have been documented for Caucasians, Asians, and Africans population. On the other hand, data on Amerindians are scanty and limited to a few populations from southern areas of South America. In this report we analyze the frequencies of 11 allele variants of CYP2D6 and 4 allele variants of NAT2 genes, and the frequency of GSTM1 and GSTT1 homozygous deleted genotypes in a sample of 90 donors representing 8 Native American populations from Argentina and Paraguay, identified as Amerindians on the basis of their geographic location, genealogical data, mitochondrial- andY-chromosomeDNAmarkers. For CYP2D6, 88.6% of the total allele frequency corresponded to *1, *2, *4 and *10 variants. Average frequencies for NAT2 *4, *5, *6 and *7 alleles were 51.2%, 25%, 6.1%, and 20.1%, respectively. GSTM1 deletion ranged from 20% to 66%, while GSTT1 deletion was present in four populations in less than 50%.We assume that CYP2D6 *2, *4, *10, *14; NAT2 *5, *7 alleles and GSTM1 and GSTT1 *0/*0 genotypes are founder variants brought to America by the first Asian settlers. Fil: Bailliet, Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina Fil: Santos, María Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina Fil: Alfaro, E. L.. Universidad Nacional de Jujuy; Argentina Fil: Dipierri, J. E.. Universidad Nacional de Jujuy; Argentina Fil: Demarchi, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Antropología de Córdoba. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Instituto de Antropología de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Museo de Antropología; Argentina Fil: Carnese, F. R.. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Instituto de Ciencias Antropológicas. Sección Antropología Biológica; Argentina Fil: Bianchi, Nestor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina 2007-12 2024-08-02T01:21:38Z 2024-08-02T01:21:38Z info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11336/237358 Bailliet, Graciela; Santos, María Rita; Alfaro, E. L.; Dipierri, J. E.; Demarchi, Dario; et al.; Allele and genotype frequencies of metabolic genes in Native Americans from Argentina and Paraguay; Elsevier Science; Mutation Research. Genetic Toxicology And Environmental Mutagenesis; 627; 2; 12-2007; 171-177 1383-5718 CONICET Digital CONICET https://suquia.ffyh.unc.edu.ar/handle/suquia/174919 eng info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1383571806003974 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mrgentox.2006.11.005 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ application/pdf application/pdf Elsevier Science
spellingShingle CYP2D6
N-Acetyltransferase 2
Human
Glutathione S-transferase M1
GST theta 1
American Native Continental Ancestry Group
https://purl.org/becyt/ford/5.4
https://purl.org/becyt/ford/5
Bailliet, Graciela
Santos, María Rita
Alfaro, E. L.
Dipierri, J. E.
Demarchi, Dario
Carnese, F. R.
Bianchi, Nestor
Allele and genotype frequencies of metabolic genes in Native Americans from Argentina and Paraguay
title Allele and genotype frequencies of metabolic genes in Native Americans from Argentina and Paraguay
title_full Allele and genotype frequencies of metabolic genes in Native Americans from Argentina and Paraguay
title_fullStr Allele and genotype frequencies of metabolic genes in Native Americans from Argentina and Paraguay
title_full_unstemmed Allele and genotype frequencies of metabolic genes in Native Americans from Argentina and Paraguay
title_short Allele and genotype frequencies of metabolic genes in Native Americans from Argentina and Paraguay
title_sort allele and genotype frequencies of metabolic genes in native americans from argentina and paraguay
topic CYP2D6
N-Acetyltransferase 2
Human
Glutathione S-transferase M1
GST theta 1
American Native Continental Ancestry Group
https://purl.org/becyt/ford/5.4
https://purl.org/becyt/ford/5
url http://hdl.handle.net/11336/237358
https://suquia.ffyh.unc.edu.ar/handle/suquia/174919
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