Detection of Human Herpesvirus 6 (HHV-6) and Human Herpesvirus 7 (HHV-7) DNA in endocervical samples from a positive and negative HPV woman of Córdoba, Argentina
Fil: Biganzoli, Patricia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina.
| Main Authors: | , , , , , , , |
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| Language: | eng |
| Published: |
2025
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| Online Access: | http://hdl.handle.net/11086/556652 https://doi.org/10.1136/jclinpath-2019-205795 |
| _version_ | 1839027533018824704 |
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| author | Biganzoli, Patricia Frutos Maria Celia Venezuela Raúl Fernando Mosmann Jessica Paola Kiguen Ana Ximena Paván Jorge Ferreyra Leonardo Cuffini, Cecilia Gabriela |
| author2 | http://orcid.org/0000-0002-4902-6813 |
| author_facet | http://orcid.org/0000-0002-4902-6813 Biganzoli, Patricia Frutos Maria Celia Venezuela Raúl Fernando Mosmann Jessica Paola Kiguen Ana Ximena Paván Jorge Ferreyra Leonardo Cuffini, Cecilia Gabriela |
| author_sort | Biganzoli, Patricia |
| collection | Repositorio Digital Universitario |
| description | Fil: Biganzoli, Patricia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. |
| id | rdu-unc.556652 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2025 |
| record_format | dspace |
| spelling | rdu-unc.5566522025-07-28T21:16:25Z Detection of Human Herpesvirus 6 (HHV-6) and Human Herpesvirus 7 (HHV-7) DNA in endocervical samples from a positive and negative HPV woman of Córdoba, Argentina Biganzoli, Patricia Frutos Maria Celia Venezuela Raúl Fernando Mosmann Jessica Paola Kiguen Ana Ximena Paván Jorge Ferreyra Leonardo Cuffini, Cecilia Gabriela http://orcid.org/0000-0002-4902-6813 HERPES HPV Fil: Biganzoli, Patricia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Biganzoli, Patricia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Virología y Bacteriología Médicas; Argentina. Fil: Frutos, Maria Celia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Venezuela, Raúl Fernando. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Mosmann, Jessica Paola. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Kiguen, Ana Ximena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Paván, Jorge. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Paván, Jorge. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Virología y Bacteriología Médicas; Argentina. Fil: Ferreyra, Leonardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Virología y Bacteriología Médicas; Argentina. Fil: Ferreyra, Leonardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Cuffini, Cecilia Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Aims: The purpose of the present study was to elucidate the presence of human herpesvirus 6A (HHV-6A), HHV-6B and HHV-7 in samples of the uterine cervix through detection of viral DNA. We analysed normal tissues, samples with low-grade squamous intraepithelial lesions (LSILs) and high-grade squamous intraepithelial lesions (HSILs). We correlated the presence of HHV-6 and HHV-7 with the finding of human papillomavirus (HPV) in mucosal samples. Methods: Cervical samples were examined and grouped as follows: group 1 (n=29), normal cytology; group 2 (n=61), samples with LSIL; group 3 (n=35), samples with HSIL. Molecular biology examinations were performed in all samples to detect HHV-6, HHV-7 and HPV DNA and to typify HHV-6 species. Results: Group 1: normal cytology and HPV (−): HHV-6: 6.8% (2/29), HHV-7: 79.3% (23/29); group 2: LSIL and HPV (−): HHV-6: 93.1% (27/29), HHV-7: 96.5% (28/29); LSIL and HPV (+): HHV-6: 0% (0/32), HHV-7: 90.6% (29/32); group 3: HSIL and HPV (−): HHV-6: 20% (2/10), HHV-7: 70% (7/10); HSIL HPV (+): HHV-6: 12% (3/25), HHV-7: 68% (17/25). HHV-6A DNA was not detected in any samples. Conclusions: (1) Both HHV-6 and HHV-7 infect the mucosal cells of the cervix with higher prevalence of HHV-7. (2) The higher prevalence of HHV-6 in LSIL HPV (−) samples compared with those with normal cytology indicates that it constitutes a possible risk factor for atypia production. (3) The presence of HHV-7 in all samples questions its role in the production of atypia. (4) The finding of HHV-6 and HHV-7 suggests that the cervical mucosa is a possible transmission pathway for these viruses. Fil: Biganzoli, Patricia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Biganzoli, Patricia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Virología y Bacteriología Médicas; Argentina. Fil: Frutos, Maria Celia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Venezuela, Raúl Fernando. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Mosmann, Jessica Paola. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Kiguen, Ana Ximena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Paván, Jorge. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Paván, Jorge. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Virología y Bacteriología Médicas; Argentina. Fil: Ferreyra, Leonardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Virología y Bacteriología Médicas; Argentina. Fil: Ferreyra, Leonardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Cuffini, Cecilia Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Virología 2025-07-28T20:16:59Z 2025-07-28T20:16:59Z 2019 Biganzoli P, Frutos MC, Venezuela F, et al Detection of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) DNA in endocervical samples from a positive and negative HPV woman of Córdoba, Argentina Journal of Clinical Pathology 2020;73:30-34. http://hdl.handle.net/11086/556652 https://doi.org/10.1136/jclinpath-2019-205795 eng Attribution-NonCommercial-ShareAlike 4.0 International https://creativecommons.org/licenses/by-nc-sa/4.0/ Electrónico y/o Digital |
| spellingShingle | HERPES HPV Biganzoli, Patricia Frutos Maria Celia Venezuela Raúl Fernando Mosmann Jessica Paola Kiguen Ana Ximena Paván Jorge Ferreyra Leonardo Cuffini, Cecilia Gabriela Detection of Human Herpesvirus 6 (HHV-6) and Human Herpesvirus 7 (HHV-7) DNA in endocervical samples from a positive and negative HPV woman of Córdoba, Argentina |
| title | Detection of Human Herpesvirus 6 (HHV-6) and Human Herpesvirus 7 (HHV-7) DNA in endocervical samples from a positive and negative HPV woman of Córdoba, Argentina |
| title_full | Detection of Human Herpesvirus 6 (HHV-6) and Human Herpesvirus 7 (HHV-7) DNA in endocervical samples from a positive and negative HPV woman of Córdoba, Argentina |
| title_fullStr | Detection of Human Herpesvirus 6 (HHV-6) and Human Herpesvirus 7 (HHV-7) DNA in endocervical samples from a positive and negative HPV woman of Córdoba, Argentina |
| title_full_unstemmed | Detection of Human Herpesvirus 6 (HHV-6) and Human Herpesvirus 7 (HHV-7) DNA in endocervical samples from a positive and negative HPV woman of Córdoba, Argentina |
| title_short | Detection of Human Herpesvirus 6 (HHV-6) and Human Herpesvirus 7 (HHV-7) DNA in endocervical samples from a positive and negative HPV woman of Córdoba, Argentina |
| title_sort | detection of human herpesvirus 6 hhv 6 and human herpesvirus 7 hhv 7 dna in endocervical samples from a positive and negative hpv woman of c oacute rdoba argentina |
| topic | HERPES HPV |
| url | http://hdl.handle.net/11086/556652 https://doi.org/10.1136/jclinpath-2019-205795 |
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