Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase
This is a preprint article, it offers immediate access but has not been peer reviewed. All content on this site: Copyright © 2023 Elsevier Inc., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open ac...
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| Format: | info:eu-repo/semantics/publishedVersion |
| Language: | spa |
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SSRN - Elsevier
2024
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| Online Access: | http://hdl.handle.net/11086/552351 https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4848610 http://dx.doi.org/10.2139/ssrn.4848610 |
| _version_ | 1802926364357033984 |
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| author | Romero, Jorge Miguel |
| author_facet | Romero, Jorge Miguel |
| author_sort | Romero, Jorge Miguel |
| collection | Repositorio Digital Universitario |
| description | This is a preprint article, it offers immediate access but has not been peer reviewed.
All content on this site: Copyright © 2023 Elsevier Inc., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the Creative Commons licensing terms apply. |
| format | info:eu-repo/semantics/publishedVersion |
| id | rdu-unc.552351 |
| institution | Universidad Nacional de Cordoba |
| language | spa |
| publishDate | 2024 |
| publisher | SSRN - Elsevier |
| record_format | dspace |
| spelling | rdu-unc.5523512024-06-21T06:25:36Z Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase Romero, Jorge Miguel Triosephosphate isomerase deficiency X-ray crystallization Stability Flexibility This is a preprint article, it offers immediate access but has not been peer reviewed. All content on this site: Copyright © 2023 Elsevier Inc., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the Creative Commons licensing terms apply. info:eu-repo/semantics/publishedVersion Fil: Romero, Jorge Miguel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica Ranwel Caputto, Argentina. Fil: Romero, Jorge Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica de Córdoba, Argentina. Human triosephosphate isomerase G122R, also known as TPI-Manchester, is a thermolabile variant detected in a screening of more than 3,400 individuals from a population in Ann Arbor, Michigan. Here, the crystallographic structure of G122R was solved to determine the molecular basis of its thermal stability. Structural analysis revealed an increase in the flexibility of residues at the dimer interface, even though R122 is about 20 Å away, suggesting that long-range electrostatic interactions may play a key role in the mutation effect. info:eu-repo/semantics/publishedVersion Fil: Romero, Jorge Miguel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica Ranwel Caputto, Argentina. Fil: Romero, Jorge Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica de Córdoba, Argentina. 2024-06-20T18:58:59Z 2024-06-20T18:58:59Z 2024-05-30 article Romero, Jorge Miguel, Structural Analysis of the Tpi-Manchester, a Thermolabile Variant of Human Triosephosphate Isomerase. Available at SSRN: https://ssrn.com/abstract=4848610 or http://dx.doi.org/10.2139/ssrn.4848610 http://hdl.handle.net/11086/552351 https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4848610 http://dx.doi.org/10.2139/ssrn.4848610 spa Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ SSRN - Elsevier |
| spellingShingle | Triosephosphate isomerase deficiency X-ray crystallization Stability Flexibility Romero, Jorge Miguel Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase |
| title | Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase |
| title_full | Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase |
| title_fullStr | Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase |
| title_full_unstemmed | Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase |
| title_short | Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase |
| title_sort | structural analysis of the tpi manchester a thermolabile variant of human triosephosphate isomerase |
| topic | Triosephosphate isomerase deficiency X-ray crystallization Stability Flexibility |
| url | http://hdl.handle.net/11086/552351 https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4848610 http://dx.doi.org/10.2139/ssrn.4848610 |
| work_keys_str_mv | AT romerojorgemiguel structuralanalysisofthetpimanchesterathermolabilevariantofhumantriosephosphateisomerase |