Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study
Fil: Lassen, Oscar. Hospital Córdoba. Centro de Chagas e Hipertensión. Departamento de Semiología; Argentina.
| Main Authors: | , , , , , , , |
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| Format: | publishedVersion |
| Language: | eng |
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2022
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| Online Access: | http://hdl.handle.net/11086/23477 https://doi.org/10.9734/BJMMR/2016/20520 |
| _version_ | 1801214099373162496 |
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| author | Lassen, Oscar Herrera, Jimena Dotto, Gladys Ojeda, Silvia María Garutti, Alicia Bertolotto, Patricia Isolina Tabares, Sandra Sembaj, Adela |
| author_facet | Lassen, Oscar Herrera, Jimena Dotto, Gladys Ojeda, Silvia María Garutti, Alicia Bertolotto, Patricia Isolina Tabares, Sandra Sembaj, Adela |
| author_sort | Lassen, Oscar |
| collection | Repositorio Digital Universitario |
| description | Fil: Lassen, Oscar. Hospital Córdoba. Centro de Chagas e Hipertensión. Departamento de Semiología; Argentina. |
| format | publishedVersion |
| id | rdu-unc.23477 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2022 |
| record_format | dspace |
| spelling | rdu-unc.234772022-10-13T11:08:54Z Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study Lassen, Oscar Herrera, Jimena Dotto, Gladys Ojeda, Silvia María Garutti, Alicia Bertolotto, Patricia Isolina Tabares, Sandra Sembaj, Adela Endothelin-1 gene Endothelin receptor a gene Genetic variation Hypertension publishedVersion Fil: Lassen, Oscar. Hospital Córdoba. Centro de Chagas e Hipertensión. Departamento de Semiología; Argentina. Fil: Herrera, Jimena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Dotto, Gladys. Hospital Córdoba. Laboratorio Central; Argentina. Fil: Ojeda, Silvia María. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Fil: Garutti, Alicia. Hospital Córdoba. Laboratorio Central; Argentina. Fil: Bertolotto, Patricia Isolina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Fil: Tabares, Sandra. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Sembaj, Adela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Aims: Endothelin-1 (ET-1) is a potent vasoconstrictive peptide, and its activity is mediated by the type A receptor (EDNRA). This action may play a significant role in the etiology of hypertension. There are different works that shows an association between certain polymorphisms of endothelin axis and clinical phenotype of hypertension. We describe the genetic variability +138/ex1 insertion/deletion (I/D) adenosine (A) in the ET-1 gene and polymorphism thymidine/cytosine (T/C) His323His in the EDNRA gene associated at the clinical variability in hypertensive patients. Study Design: Observational, transversal and analytical study. Place and Duration of Study: Hypertension Service at the Internal Medicine Department of Córdoba Hospital, and Biochemical and Molecular Biology Department in School of Medicine, National University of Cordoba, Argentine. Patients considered hypertensive between April 2009 and April 2010. Methodology: Were assessed 136 patients serum lipid profiles, renal and hepatic functions and were taken Thoracic X-rays, electrocardiograms, and echocardiographs. DNA extracted from circulating leukocyte were used to analyze the polymorphisms of genes by PCR-RFLP. Results: For the polymorphisms of Receptor A from Endothelin -1 studied the presence of cytosine homozygous genotype was less frequent in males (P = .02). For both genders, the same genotype was associated to low plasma alkaline phosphatase activity and cholesterol levels. The presence of thymidine nucleotide allele correlated with plasma alkaline phosphatase activity and cholesterol levels. The Thymidine allele correlated with the degree of cardiovascular compromise (r = 0.54, P= .002). For the genetic variant in the ET-1 gene, the homozygous adenine deletion was associated to normal plasma levels of glutamate/pyruvate transaminase enzyme activity, uric acid concentration, cholesterol, and Low Density Lipoprotein in hypertensive subjects without clinical risk. Conclusion: We observed a gender-specific protective effect for EDNRA gene variations, the subjects that carried the TT genotype presented more aggressive symptomatology. These results show an association between plasmatic biochemical parameters, the clinical condition, and polymorphisms in the endothelin axis genes. publishedVersion Fil: Lassen, Oscar. Hospital Córdoba. Centro de Chagas e Hipertensión. Departamento de Semiología; Argentina. Fil: Herrera, Jimena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Dotto, Gladys. Hospital Córdoba. Laboratorio Central; Argentina. Fil: Ojeda, Silvia María. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Fil: Garutti, Alicia. Hospital Córdoba. Laboratorio Central; Argentina. Fil: Bertolotto, Patricia Isolina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Fil: Tabares, Sandra. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Sembaj, Adela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Bioquímica y Biología Molecular 2022-03-29T14:18:45Z 2022-03-29T14:18:45Z 2016 article Lassen, O., Herrera, J., Dotto, G., Ojeda, S. M., Garutti, A. Bertolotto, P. I. y otros. (2016). Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study. British Journal of Medicine & Medical Research, 11 (7), 1-8. https://doi.org/10.9734/BJMMR/2016/20520 http://hdl.handle.net/11086/23477 https://doi.org/10.9734/BJMMR/2016/20520 eng Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ Electrónico y/o Digital ISSN 2231-0614 |
| spellingShingle | Endothelin-1 gene Endothelin receptor a gene Genetic variation Hypertension Lassen, Oscar Herrera, Jimena Dotto, Gladys Ojeda, Silvia María Garutti, Alicia Bertolotto, Patricia Isolina Tabares, Sandra Sembaj, Adela Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study |
| title | Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study |
| title_full | Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study |
| title_fullStr | Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study |
| title_full_unstemmed | Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study |
| title_short | Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study |
| title_sort | plasmatic biochemical variables associated with polymorphisms in the endothelin 1 and endothelin 1 receptor a genes in hypertensive patients pilot study |
| topic | Endothelin-1 gene Endothelin receptor a gene Genetic variation Hypertension |
| url | http://hdl.handle.net/11086/23477 https://doi.org/10.9734/BJMMR/2016/20520 |
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