Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats
It has been suggested that some addictive properties of ethanol (EtOH) are modulated by 5-HT1B receptors in the nucleus accumbens (nAcc). This research was designed to assess the effects of systemic and intra-accumbal administration of the 5-HT1B receptor agonist CP94253 on the oral self-administrat...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | spa |
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Instituto de Investigaciones Psicológicas
2022
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| Subjects: | |
| Online Access: | https://revistas.unc.edu.ar/index.php/racc/article/view/30138 |
| _version_ | 1841852937196797952 |
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| author | Jiménez, Juan C. Cortés-Salazar, Felipe Cedillo-Ildefonso, Benita Miranda, Florencio |
| author_facet | Jiménez, Juan C. Cortés-Salazar, Felipe Cedillo-Ildefonso, Benita Miranda, Florencio |
| author_sort | Jiménez, Juan C. |
| collection | Portal de Revistas |
| description | It has been suggested that some addictive properties of ethanol (EtOH) are modulated by 5-HT1B receptors in the nucleus accumbens (nAcc). This research was designed to assess the effects of systemic and intra-accumbal administration of the 5-HT1B receptor agonist CP94253 on the oral self-administration of EtOH in rats. Male Wistar rats were water deprived for 24 h, and then trained to lever-press for EtOH reinforcement on a FR3 schedule until response rate remained stable at 80%. After this training, a group of rats received an intraperitoneal injection of 5-HT1B receptor agonist CP94253 before rats were under FR3 schedule of reinforcement for EtOH access. Another group of rats, after similar training, received intra-accumbal injection of CP94253. The data showed that both systemic and intra-accumbal injections reduced oral self-administration of EtOH. These findings suggest that the 5-HT1B receptors activation may modulate the reduction of oral self-administration of EtOH in rats. |
| format | Online |
| id | oai:ojs.revistas.unc.edu.ar:article-30138 |
| institution | Universidad Nacional de Cordoba |
| language | spa |
| publishDate | 2022 |
| publisher | Instituto de Investigaciones Psicológicas |
| record_format | ojs |
| spelling | oai:ojs.revistas.unc.edu.ar:article-301382022-04-22T21:59:46Z Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats La administración sistémica e intra-accumbens del agonista 5-HT1B CP94253 modula la auto-administración oral de etanol en ratas Jiménez, Juan C. Cortés-Salazar, Felipe Cedillo-Ildefonso, Benita Miranda, Florencio 5-HT1B receptors EtOH nAcc self-administration receptores 5-HT1B EtOH nAcc auto-administración It has been suggested that some addictive properties of ethanol (EtOH) are modulated by 5-HT1B receptors in the nucleus accumbens (nAcc). This research was designed to assess the effects of systemic and intra-accumbal administration of the 5-HT1B receptor agonist CP94253 on the oral self-administration of EtOH in rats. Male Wistar rats were water deprived for 24 h, and then trained to lever-press for EtOH reinforcement on a FR3 schedule until response rate remained stable at 80%. After this training, a group of rats received an intraperitoneal injection of 5-HT1B receptor agonist CP94253 before rats were under FR3 schedule of reinforcement for EtOH access. Another group of rats, after similar training, received intra-accumbal injection of CP94253. The data showed that both systemic and intra-accumbal injections reduced oral self-administration of EtOH. These findings suggest that the 5-HT1B receptors activation may modulate the reduction of oral self-administration of EtOH in rats. moduladas por receptores 5-HT1B en el núcleo accumbens (nAcc). Esta investigación se diseñó para evaluar los efectos de la administración sistémica e intra-accumbens del agonista 5-HT1B CP94253 en la auto-administración oral de EtOH. Se utilizaron ratas machos Wistar que se privaron de agua por 24 h, y se entrenaron a presionar una palanca para obtener EtOH como reforzador hasta que la tasa de respuestas permaneció estable al 80%. Después, a un grupo de ratas se les administró una inyección intraperitoneal del agonista 5-HT1B CP94253 antes de someterse al programa RF3 (razón fija 3) con EtOH como reforzador. Otro grupo de ratas, después de un entrenamiento similar, se les administró una inyección intra-accumbens de CP94253. Los datos indicaron que tanto la inyección sistémica como la intra-accumbens de CP94253 redujeron la auto-administración oral de EtOH. Esto sugiere que los receptores 5-HT1B podrían participar en la modulación de la auto-administración oral de EtOH. Instituto de Investigaciones Psicológicas 2022-04-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/racc/article/view/30138 10.32348/1852.4206.v14.n1.30138 Argentinean Journal of Behavioral Sciences; Vol. 14 No. 1 (2022): REVISTA ARGENTINA DE CIENCIAS DEL COMPORTAMIENTO; 68-81 Revista Argentina de Ciencias del Comportamiento; Vol. 14 Núm. 1 (2022): REVISTA ARGENTINA DE CIENCIAS DEL COMPORTAMIENTO; 68-81 1852-4206 10.32348/1852.4206.v14.n1 spa https://revistas.unc.edu.ar/index.php/racc/article/view/30138/37569 Derechos de autor 2022 Juan C. Jiménez, Felipe Cortés-Salazar, Benita Cedillo-Ildefonso, Florencio Miranda http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | 5-HT1B receptors EtOH nAcc self-administration receptores 5-HT1B EtOH nAcc auto-administración Jiménez, Juan C. Cortés-Salazar, Felipe Cedillo-Ildefonso, Benita Miranda, Florencio Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats |
| title | Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats |
| title_alt | La administración sistémica e intra-accumbens del agonista 5-HT1B CP94253 modula la auto-administración oral de etanol en ratas |
| title_full | Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats |
| title_fullStr | Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats |
| title_full_unstemmed | Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats |
| title_short | Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats |
| title_sort | systemic and intra accumbal administration of the 5 ht1b receptor agonist cp94253 modulates oral self administration of ethanol in rats |
| topic | 5-HT1B receptors EtOH nAcc self-administration receptores 5-HT1B EtOH nAcc auto-administración |
| topic_facet | 5-HT1B receptors EtOH nAcc self-administration receptores 5-HT1B EtOH nAcc auto-administración |
| url | https://revistas.unc.edu.ar/index.php/racc/article/view/30138 |
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