“…Altering the integrity of solidpharmaceutical forms (dividing tablets or patches, crushing tablets, etc.) is common and sometimes unjustifiedwithin the hospital setting, due to a shortage of liquid formulations in patients with swallowing problems, orbecause the requiring dosage differs from commercial ones or those available in hospital pharmacies. Handling solidpharmaceutical forms may affect their physicochemical and biopharmaceutical properties, the pharmacologicaleffect; and sometimes, it may cause undesirable side effects. …”
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