Selective and non-selective evolutionary signatures found in the simplest replicative biological entities
Fil: Jacquat, Andrés Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.
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| Format: | info:eu-repo/semantics/acceptedVersion |
| Language: | eng |
| Published: |
2025
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| Online Access: | http://hdl.handle.net/11086/556463 https://doi.org/10.1093/jeb/voae070 |
| _version_ | 1837938407429373952 |
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| author | Jacquat, Andrés Gustavo Theumer, Martín Gustavo Dambolena, José Sebastián |
| author2 | https://orcid.org/0000-0001-6811-9604 |
| author_facet | https://orcid.org/0000-0001-6811-9604 Jacquat, Andrés Gustavo Theumer, Martín Gustavo Dambolena, José Sebastián |
| author_sort | Jacquat, Andrés Gustavo |
| collection | Repositorio Digital Universitario |
| description | Fil: Jacquat, Andrés Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. |
| format | info:eu-repo/semantics/acceptedVersion |
| id | rdu-unc.556463 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2025 |
| record_format | dspace |
| spelling | rdu-unc.5564632025-07-16T21:18:11Z Selective and non-selective evolutionary signatures found in the simplest replicative biological entities Jacquat, Andrés Gustavo Theumer, Martín Gustavo Dambolena, José Sebastián https://orcid.org/0000-0001-6811-9604 https://orcid.org/0000-0002-9653-8766 https://orcid.org/0000-0001-8690-6564 Natural selection Neutral selection Mutation pressure Selective pressure Mitoviruses Kvaramitovirus, Mitoviridae Codon usage bias Genomic signatures Secondary structure info:eu-repo/semantics/acceptedVersion Fil: Jacquat, Andrés Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Fil: Jacquat, Andrés Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina. Fil: Theumer, Martín Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina Fil: Theumer, Martín Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Fil: Dambolena, José Sebastián. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Fil: Dambolena, José Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina. Mitoviruses, which are considered evolutionary relics of extinct alpha-proteobacteria RNA phages, represent one of the simplest self-replicating biological systems. This study aims to quantitatively describe genomes and identify potential genomic signatures that support the protein phylogenetic-based classifcation criterion. Genomic variables, such as mononucleotide and dinucleotide composition, codon usage bias, and minimal free energy derived from optimized predicted RNA secondary structure, were analyzed. From the values obtained, the main evolutionary pressures were discussed, indicating that natural selection plays a signifcant role in shaping mitovirus genomes. However, neutral evolution also makes a signifcant contribution. This study reveals a signifcant discovery of structural divergence in Kvaramitovirus. The energy minimization approach employed to study 2D folding in this study reveals a distinct spatial organization of their genomes, providing evidence for the hypothesis of a single evolutionary event of circularization in the most recent common ancestor of the lineage. This hypothesis was discussed in light of recent discoveries by other researchers that partially support the existence of mitoviruses with circular genomes. Finally, this study represents a signifcant advancement in the understanding of mitoviruses, as it quantitatively describes the nucleotide sequence at the family and genus taxonomic levels. Additionally, we provide hypotheses that can be experimentally validated to inspire new research and address the gaps in knowledge of this fascinating, basally divergent RNA virus lineage. info:eu-repo/semantics/acceptedVersion Fil: Jacquat, Andrés Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Fil: Jacquat, Andrés Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina. Fil: Theumer, Martín Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina Fil: Theumer, Martín Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Fil: Dambolena, José Sebastián. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Fil: Dambolena, José Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina. 2025-07-16T14:16:22Z 2025-07-16T14:16:22Z 2024-06-01 article urn:issn:1420-9101 Andrés Gustavo Jacquat, Martín Gustavo Theumer, José Sebastián Dambolena, Selective and non-selective evolutionary signatures found in the simplest replicative biological entities, Journal of Evolutionary Biology, Volume 37, Issue 8, August 2024, Pages 862–876, https://doi.org/10.1093/jeb/voae070 1420-9101 http://hdl.handle.net/11086/556463 https://doi.org/10.1093/jeb/voae070 eng Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spellingShingle | Natural selection Neutral selection Mutation pressure Selective pressure Mitoviruses Kvaramitovirus, Mitoviridae Codon usage bias Genomic signatures Secondary structure Jacquat, Andrés Gustavo Theumer, Martín Gustavo Dambolena, José Sebastián Selective and non-selective evolutionary signatures found in the simplest replicative biological entities |
| title | Selective and non-selective evolutionary signatures found in the simplest replicative biological entities |
| title_full | Selective and non-selective evolutionary signatures found in the simplest replicative biological entities |
| title_fullStr | Selective and non-selective evolutionary signatures found in the simplest replicative biological entities |
| title_full_unstemmed | Selective and non-selective evolutionary signatures found in the simplest replicative biological entities |
| title_short | Selective and non-selective evolutionary signatures found in the simplest replicative biological entities |
| title_sort | selective and non selective evolutionary signatures found in the simplest replicative biological entities |
| topic | Natural selection Neutral selection Mutation pressure Selective pressure Mitoviruses Kvaramitovirus, Mitoviridae Codon usage bias Genomic signatures Secondary structure |
| url | http://hdl.handle.net/11086/556463 https://doi.org/10.1093/jeb/voae070 |
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