Epidemiología del virus encefalitis Saint Louis en la provincia de Córdoba
Tesis - Doctorado en Ciencias de la Salud - Universidad nacional de Córdoba. Facultad de Ciencias Médicas. Secretaría de Graduados en Ciencias de la Salud, 2009
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| Format: | doctoralThesis |
| Language: | spa |
| Published: |
2024
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| Online Access: | http://hdl.handle.net/11086/553881 |
| _version_ | 1825131998736285696 |
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| author | Spinsanti, Lorena Ivana |
| author2 | Contigiani, Marta Silvia |
| author_facet | Contigiani, Marta Silvia Spinsanti, Lorena Ivana |
| author_sort | Spinsanti, Lorena Ivana |
| collection | Repositorio Digital Universitario |
| description | Tesis - Doctorado en Ciencias de la Salud - Universidad nacional de Córdoba. Facultad de Ciencias Médicas. Secretaría de Graduados en Ciencias de la Salud, 2009 |
| format | doctoralThesis |
| id | rdu-unc.553881 |
| institution | Universidad Nacional de Cordoba |
| language | spa |
| publishDate | 2024 |
| record_format | dspace |
| spelling | rdu-unc.5538812024-10-19T06:24:20Z Epidemiología del virus encefalitis Saint Louis en la provincia de Córdoba Spinsanti, Lorena Ivana Contigiani, Marta Silvia Encefalitis de San Luis Encefalitis de San Luis; epidemiología Flavivirus Infecciones por Flavivirus; complicaciones Argentina, epidemiología Tesis - Doctorado en Ciencias de la Salud - Universidad nacional de Córdoba. Facultad de Ciencias Médicas. Secretaría de Graduados en Ciencias de la Salud, 2009 149 h. : ilus., 30 cm Fil: Spinsanti, Lorena Ivana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina. El virus encefalitis St. Louis (Flavivirus) circula desde Canadá hasta Argentina. En nuestro país se ha demostrado su endemicidad por los hallazgos serológicos y virológicos en distintas provincias. Sin embargo los registros de casos clínicos han sido muy escasos. Uno de los principales Objetivos de esta tesis fue conocer el rol de este agente en las patología febriles y neurológicas de pacientes de la provincia de Córdoba. Desde el año 2002 hasta el año 2007 se detectaron anticuerpos tipo IgM en 68 pacientes y se confirmó la infección por VESL en 19 pacientes. La mayoría de los casos ocurrieron durante un brote que produjo este virus en el año 2005. Con la utilización de información sobre variables ambientales derivadas de sensores remotos (SR) y sistemas de información geogrçáfico (SIG) se generaron mapas de susceptibilidad macroambiental a la transmisión de VESL en la ciudad de Córdoba. Se encontró un asociación directa entre el número de humanos infectados y la cercanía a fuentes de vegetación vigorosa y densa. El mapa de susceptibilidad ambiental para la incidencia infección con VESL clasificó el 66% de la ciudad bajo riesgo alto, medio alto y medio y 34% con riesgo bajo o sin riesgo de infección. Del total de los casos ocurridos durante la epidemia de 2005, el 94% de los mismos fueron notificados en áreas predichas por el modelo como riesgo medio, medio alto y alto. St. Louis encephalitis virus (SLEV) (Flavivirus) circulates from Canada all through Argentina. In this country, its endemicity has been demonstrated by serological and viral findings in several provinces. However, clinical cases have been scarcely reported. One of the main objectives of this thesis was to recognize the role of SLEV as responsible for neurological and febrile diseases in the province of Córdoba. Between years 2002 and 2007, IgM antibodies were detected in 68 patients and SLEV infection was confirmed in 19 of them; most of the cases occurred during the 2005 outbreak. Maps of ambient susceptibility to SLEV transmission for the city of Córdoba were elaborated with the use of information about ambient conditions provided by remote sensors (RS) and systems of geographic information (SGI). A direct association between the number of infected humans and neighboring sources of dense and vigorous vegetation was detected. The map of ambient susceptibility for SLEV infection placed 66% of the citizens under high, moderate/high and moderate risk of acquiring the infection and 34% at low or without risk. Ninety four percent of the cases occurred during the 2005 outbreak and belonged to areas placed as at moderate, high/moderate and high risk. The serological survey performed in 2003 to individuals who attended to Health Care Centers (HCC) of the city of Córdoba demonstrated a prevalence of neutralizing antibodies (NT Ab) of 13.3%. During 2004, it was established that the risk factors associated to SLEV infection in the populations of HCC 40 (Las Flores) and 58 (Maldonado) were outdoor activities at night and the presence of trash deposits close to housing areas. It was also demonstrated that individuals who lived in the area of HCC 58 were at higher risk of acquiring the infection. In both HCCs, the prevalence of IgM and NT antibodies increased during the 2005 outbreak, indicating the concomitant occurrence of asymptomatic infections. In some patients, the persistence of IgM antibodies longer than a year was demonstrated. However, the titers of IgG antibodies (Isotypes IgG1 and IgG4), both elevated between days 8 and 30 after the infection allowed differentiating acute and past infections, especially in cases of asymptomatic patients. LIS 4 On the other side, a technique of RT-Nested PCR for the detection of the specific viral genome was developed. Excellent results were obtained using supernatant of cells infected with different strains of SLEV, even though this did not occur with clinical specimens. In conclusion, these studies allowed recognizing the participation of this virus in undifferentiated neurological and febrile diseases that occur during summer-autumn and affect mainly the elderly, with an important number of asymptomatic infections. In the province of Córdoba, like in the US, SLEV produces small outbreaks and sporadic interepidemic cases. The construction of macro ambient maps of susceptibility to SLEV infection represented an approximation to the applications of SR ad SIG for the construction of predictive maps useful for Public Health procedures. The knowledge of the profile of the isotypic immune response could be useful for diagnosis, due to the persistence of IgM antibodies. The percentage of Córdoba inhabitants at high risk of acquiring SLEV due to ambient factors, outdoor activities at night and the proximity of trash deposits detected in some areas, in addition the circulation of Dengue and West Nile viruses represents a very relevant result for the continuous surveillance of febrile and neurological syndromes. Fil: Spinsanti, Lorena Ivana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina. 2024-10-08T21:05:48Z 2024-10-08T21:05:48Z 2009 doctoralThesis http://hdl.handle.net/11086/553881 spa Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spellingShingle | Encefalitis de San Luis Encefalitis de San Luis; epidemiología Flavivirus Infecciones por Flavivirus; complicaciones Argentina, epidemiología Spinsanti, Lorena Ivana Epidemiología del virus encefalitis Saint Louis en la provincia de Córdoba |
| title | Epidemiología del virus encefalitis Saint Louis en la provincia de Córdoba |
| title_full | Epidemiología del virus encefalitis Saint Louis en la provincia de Córdoba |
| title_fullStr | Epidemiología del virus encefalitis Saint Louis en la provincia de Córdoba |
| title_full_unstemmed | Epidemiología del virus encefalitis Saint Louis en la provincia de Córdoba |
| title_short | Epidemiología del virus encefalitis Saint Louis en la provincia de Córdoba |
| title_sort | epidemiologia del virus encefalitis saint louis en la provincia de cordoba |
| topic | Encefalitis de San Luis Encefalitis de San Luis; epidemiología Flavivirus Infecciones por Flavivirus; complicaciones Argentina, epidemiología |
| url | http://hdl.handle.net/11086/553881 |
| work_keys_str_mv | AT spinsantilorenaivana epidemiologiadelvirusencefalitissaintlouisenlaprovinciadecordoba |