Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs
2023. Impact factor: 2.7
| Main Authors: | , , , |
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| Format: | info:eu-repo/semantics/publishedVersion |
| Language: | eng |
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Royal Society of Chemistry and the Centre National de la Recherche Scientifique
2024
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| Online Access: | http://hdl.handle.net/11086/553238 https://pubs.rsc.org/en/content/articlehtml/2024/nj/d3nj04434c https://pubs.rsc.org/en/content/articlelanding/2024/nj/d3nj04434c/unauth https://www.rsc.org/suppdata/d3/nj/d3nj04434c/d3nj04434c1.pdf https://doi.org/10.1039/D3NJ04434C |
| _version_ | 1808112624702849024 |
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| author | Mosconi, Giuliana Formica, María Lina Palma, Santiago D. Rojas, Ricardo |
| author2 | https://orcid.org/0000-0001-7225-0998 |
| author_facet | https://orcid.org/0000-0001-7225-0998 Mosconi, Giuliana Formica, María Lina Palma, Santiago D. Rojas, Ricardo |
| author_sort | Mosconi, Giuliana |
| collection | Repositorio Digital Universitario |
| description | 2023. Impact factor: 2.7 |
| format | info:eu-repo/semantics/publishedVersion |
| id | rdu-unc.553238 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2024 |
| publisher | Royal Society of Chemistry and the Centre National de la Recherche Scientifique |
| record_format | dspace |
| spelling | rdu-unc.5532382024-08-10T06:25:53Z Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs Mosconi, Giuliana Formica, María Lina Palma, Santiago D. Rojas, Ricardo https://orcid.org/0000-0001-7225-0998 https://orcid.org/0000-0003-3161-6425 https://orcid.org/0000-0003-2767-9087 https://orcid.org/0000-0001-5826-2036 Drug delivery Layered double hydroxides (LDHs) Rheological properties Sustained release Mucoadhesion 2023. Impact factor: 2.7 info:eu-repo/semantics/publishedVersion Fil: Mosconi, Giuliana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Mosconi, Giuliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Fisicoquímica de Córdoba; Argentina. Fil: Formica, María Lina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Formica, María Lina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Palma, Santiago D. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Palma Santiago D. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Rojas, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Rojas, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Fisicoquímica de Córdoba; Argentina. Drug delivery to ocular tissues is mainly hindered by anatomical and physiological barriers that diminish their bioavailability. In this work, layered double hydroxides (LDHs) intercalated with non-steroidal anti-inflammatory drugs (NSAIDs; ibuprofen, ketoprofen, and ketorolac) were incorporated into carboxymethylcellulose (CMC) dispersions with the aim of adjusting their rheological properties, producing sustained release, and inducing mucoadhesive properties. Pure NSAID-intercalated LDHs (LDH-NSAID) with high drug loading were obtained. The obtained particles showed high aggregation and positive surface charges, which allowed interaction with the negatively charged groups of CMC. Isotonic 1% CMC and 1% LDH-NSAID (w/w) dispersions behaved as viscous, shear-thinning fluids, although a stronger interaction with ketoprofen led to more gel-like behavior. Also, CMC/LDH-NSAID dispersions exhibited a more sustained drug release than that achieved with analogous formulations containing pure drugs, and the modeling of the profile indicated that the release rate was mainly determined by the anion exchange of the intercalated NSAID. Finally, the formulations showed strong mucoadhesion capacity, as they produce significant changes in the zeta potential of mucin dispersions. Further optimization of the particle size and surface properties of the particles is required to modulate the release profile and to enhance the rheological properties of these CMC/LDH-based formulations. info:eu-repo/semantics/publishedVersion Fil: Mosconi, Giuliana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Mosconi, Giuliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Fisicoquímica de Córdoba; Argentina. Fil: Formica, María Lina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Formica, María Lina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Palma, Santiago D. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Palma Santiago D. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Rojas, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Rojas, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Fisicoquímica de Córdoba; Argentina. 2024-08-09T20:11:47Z 2024-08-09T20:11:47Z 2023-11-24 article Mosconi, G., Formica, M. L., Palma, S. D., & Rojas, R. (2024). Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs. New Journal of Chemistry, 48(1), 406-415. http://hdl.handle.net/11086/553238 1369-9261 https://pubs.rsc.org/en/content/articlehtml/2024/nj/d3nj04434c https://pubs.rsc.org/en/content/articlelanding/2024/nj/d3nj04434c/unauth https://www.rsc.org/suppdata/d3/nj/d3nj04434c/d3nj04434c1.pdf https://doi.org/10.1039/D3NJ04434C eng Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Royal Society of Chemistry and the Centre National de la Recherche Scientifique |
| spellingShingle | Drug delivery Layered double hydroxides (LDHs) Rheological properties Sustained release Mucoadhesion Mosconi, Giuliana Formica, María Lina Palma, Santiago D. Rojas, Ricardo Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs |
| title | Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs |
| title_full | Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs |
| title_fullStr | Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs |
| title_full_unstemmed | Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs |
| title_short | Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs |
| title_sort | carboxymethylcellulose layered double hydroxide dispersions for topical ocular delivery of non steroidal anti inflammatory drugs |
| topic | Drug delivery Layered double hydroxides (LDHs) Rheological properties Sustained release Mucoadhesion |
| url | http://hdl.handle.net/11086/553238 https://pubs.rsc.org/en/content/articlehtml/2024/nj/d3nj04434c https://pubs.rsc.org/en/content/articlelanding/2024/nj/d3nj04434c/unauth https://www.rsc.org/suppdata/d3/nj/d3nj04434c/d3nj04434c1.pdf https://doi.org/10.1039/D3NJ04434C |
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