Brain clocks capture diversity and disparity in aging and dementia
Fil: Ibanez, Agustin. Trinity College; Irlanda.
Main Authors: | , , , |
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Other Authors: | |
Format: | info:eu-repo/semantics/acceptedVersion |
Language: | eng |
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2024
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Online Access: | http://hdl.handle.net/11086/553109 https://www.researchsquare.com/article/rs-4150225/v1 |
_version_ | 1806648094922637312 |
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author | Ibanez, Agustin Moguilner, Sebastian Baez, Sandra Barttfeld, Pablo |
author2 | https://orcid.org/0000-0001-6758-5101 |
author_facet | https://orcid.org/0000-0001-6758-5101 Ibanez, Agustin Moguilner, Sebastian Baez, Sandra Barttfeld, Pablo |
author_sort | Ibanez, Agustin |
collection | Repositorio Digital Universitario |
description | Fil: Ibanez, Agustin. Trinity College; Irlanda. |
format | info:eu-repo/semantics/acceptedVersion |
id | rdu-unc.553109 |
institution | Universidad Nacional de Cordoba |
language | eng |
publishDate | 2024 |
record_format | dspace |
spelling | rdu-unc.5531092024-08-06T06:36:41Z Brain clocks capture diversity and disparity in aging and dementia Ibanez, Agustin Moguilner, Sebastian Baez, Sandra Barttfeld, Pablo https://orcid.org/0000-0001-6758-5101 https://orcid.org/0000-0003-1731-8325 https://orcid.org/0000-0003-0875-1709 https://orcid.org/0000-0001-8530-6938 Biological sciences Neuroscience Cognitive ageing Diseases of the nervous system Dementia Scientific community and society info:eu-repo/semantics/acceptedVersion Fil: Ibanez, Agustin. Trinity College; Irlanda. Fil: Moguilner, Sebastian. Harvard Medical School; United States. Fil: Baez, Sandra. Universidad de los Andes; Colombia. Fil: Barttfeld, Pablo. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Fil: Barttfeld, Pablo. Consejo Nacional de Investigaciones Científicas y Tecnológicas. Instituto de Investigaciones Psicológicas; Argentina. Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding brain health and disease. However, the impact of multimodal diversity (geographical, socioeconomic, sociodemographic, sex, neurodegeneration) on the brain age gap (BAG) is unknown. Here, we analyzed datasets from 5,306 participants across 15 countries (7 Latin American countries -LAC, 8 non-LAC). Based on higher-order interactions in brain signals, we developed a BAG deep learning architecture for functional magnetic resonance imaging (fMRI=2,953) and electroencephalography (EEG=2,353). The datasets comprised healthy controls, and individuals with mild cognitive impairment, Alzheimer’s disease, and behavioral variant frontotemporal dementia. LAC models evidenced older brain ages (fMRI: MDE=5.60, RMSE=11.91; EEG: MDE=5.34, RMSE=9.82) compared to non-LAC, associated with frontoposterior networks. Structural socioeconomic inequality and other disparity-related factors (pollution, health disparities) were influential predictors of increased brain age gaps, especially in LAC (R²=0.37, F²=0.59, RMSE=6.9). A gradient of increasing BAG from controls to mild cognitive impairment to Alzheimer’s disease was found. In LAC, we observed larger BAGs in females in control and Alzheimer’s disease groups compared to respective males. Results were not explained by variations in signal quality, demographics, or acquisition methods. Findings provide a quantitative framework capturing the multimodal diversity of accelerated brain aging. info:eu-repo/semantics/acceptedVersion Fil: Ibanez, Agustin. Trinity College; Irlanda. Fil: Moguilner, Sebastian. Harvard Medical School; United States. Fil: Baez, Sandra. Universidad de los Andes; Colombia. Fil: Barttfeld, Pablo. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Fil: Barttfeld, Pablo. Consejo Nacional de Investigaciones Científicas y Tecnológicas. Instituto de Investigaciones Psicológicas; Argentina. 2024-08-05T19:28:50Z 2024-08-05T19:28:50Z 2024-06-25 article http://hdl.handle.net/11086/553109 2693-5015 https://www.researchsquare.com/article/rs-4150225/v1 eng Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Biological sciences Neuroscience Cognitive ageing Diseases of the nervous system Dementia Scientific community and society Ibanez, Agustin Moguilner, Sebastian Baez, Sandra Barttfeld, Pablo Brain clocks capture diversity and disparity in aging and dementia |
title | Brain clocks capture diversity and disparity in aging and dementia |
title_full | Brain clocks capture diversity and disparity in aging and dementia |
title_fullStr | Brain clocks capture diversity and disparity in aging and dementia |
title_full_unstemmed | Brain clocks capture diversity and disparity in aging and dementia |
title_short | Brain clocks capture diversity and disparity in aging and dementia |
title_sort | brain clocks capture diversity and disparity in aging and dementia |
topic | Biological sciences Neuroscience Cognitive ageing Diseases of the nervous system Dementia Scientific community and society |
url | http://hdl.handle.net/11086/553109 https://www.researchsquare.com/article/rs-4150225/v1 |
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