Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles
Fil: Chamorro Cañon, J. David. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina.
| Main Authors: | , , , , |
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| Format: | info:eu-repo/semantics/acceptedVersion |
| Language: | eng |
| Published: |
2024
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| Online Access: | http://hdl.handle.net/11086/552898 https://pubs.acs.org/journal/jpcbfk |
| _version_ | 1806012410985709568 |
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| author | Chamorro Cañon, J. David Luna, M. Alejandra Sabini, M. Carola Molina, Patricia G. Correa, Mariano |
| author2 | https://orcid.org/0000-0001-7493-8964 |
| author_facet | https://orcid.org/0000-0001-7493-8964 Chamorro Cañon, J. David Luna, M. Alejandra Sabini, M. Carola Molina, Patricia G. Correa, Mariano |
| author_sort | Chamorro Cañon, J. David |
| collection | Repositorio Digital Universitario |
| description | Fil: Chamorro Cañon, J. David. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. |
| format | info:eu-repo/semantics/acceptedVersion |
| id | rdu-unc.552898 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2024 |
| record_format | dspace |
| spelling | rdu-unc.5528982024-07-27T06:21:27Z Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles Chamorro Cañon, J. David Luna, M. Alejandra Sabini, M. Carola Molina, Patricia G. Correa, Mariano https://orcid.org/0000-0001-7493-8964 https://orcid.org/0000-0002-1728-3620 Assays Cells Encapsulation Nanocarriers Vesicles info:eu-repo/semantics/acceptedVersion Fil: Chamorro Cañon, J. David. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Fil: Luna, M. Alejandra. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Fil: Sabini, María Carola. Universidad Nacional de Río Cuarto; Argentina. Fil: Sabini, María Carola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Molina, Patricia G. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Fil: Correa, Mariano. niversidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. 5-Fluorouracil (5-FU) is an antineoplastic agent known for its low bioavailability and limited cellular penetration, often resulting in adverse effects on healthy cells. Thus, finding vehicles that enhance bioavailability, enable controlled release, and mitigate adverse effects is crucial. The study focuses on encapsulating 5-FU within soy lecithin vesicles (SLVs) and assessing its impact on the carrier’s properties and functionality. Results show that incorporating 5-FU does not affect SLVs’ size or polydispersity, even postlyophilization. Liberation of 5-FU from SLVs requires system disruption rather than spontaneous release, with an encapsulation efficiency of approximately 43% determined using Square Wave Voltammetry. Cytotoxicity assays on colorectal cancer cells reveal SLV-based delivery’s significant efficacy, surpassing free drug solution effects with 45% cell viability after 72 h vs 73% viability. The research addresses 5-FU’s limited bioavailability by creating a biocompatible nanocarrier for efficient drug delivery, highlighting SLVs as promising for targeted cancer therapy due to sustained antiproliferative effects and improved cellular uptake. The study underscores the importance of tailored drug delivery systems in enhancing therapeutic outcomes and suggests SLV/5-FU formulations as a potential advancement in cancer treatment strategies. info:eu-repo/semantics/acceptedVersion Fil: Chamorro Cañon, J. David. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Fil: Luna, M. Alejandra. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Fil: Sabini, María Carola. Universidad Nacional de Río Cuarto; Argentina. Fil: Sabini, María Carola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Molina, Patricia G. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Fil: Correa, Mariano. niversidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. 2024-07-25T19:40:44Z 2024-07-25T19:40:44Z 2024-05-29 article J. Phys. Chem. B 2024, 128, 22, 5427–5436 1520-6106 http://hdl.handle.net/11086/552898 1520-5207 https://pubs.acs.org/journal/jpcbfk eng Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spellingShingle | Assays Cells Encapsulation Nanocarriers Vesicles Chamorro Cañon, J. David Luna, M. Alejandra Sabini, M. Carola Molina, Patricia G. Correa, Mariano Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles |
| title | Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles |
| title_full | Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles |
| title_fullStr | Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles |
| title_full_unstemmed | Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles |
| title_short | Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles |
| title_sort | electrochemical characterization of the encapsulation and release of 5 fluorouracil in nanocarriers formed from soy lecithin vesicles |
| topic | Assays Cells Encapsulation Nanocarriers Vesicles |
| url | http://hdl.handle.net/11086/552898 https://pubs.acs.org/journal/jpcbfk |
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