Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis
Impact Factor: 4.9 (2023). 5-Year Impact Factor: 5.5 (2023). Se publicó como preprint en: https://www.preprints.org/manuscript/202402.0587/v1
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | info:eu-repo/semantics/publishedVersion |
| Language: | eng |
| Published: |
Academic Editor: Vivek Verma
2024
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| Subjects: | |
| Online Access: | http://hdl.handle.net/11086/552768 https://www.mdpi.com/1999-4923/16/4/436 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11054002/ |
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| author | Magi, María S. de Lafuente, Yanina Quarta, Eride Palena, María C. Ardiles, Perla del R. Páez, Paulina L. Sonvico, Fabio Buttini, Francesca Jimenez Kairuz, Alvaro F. |
| author2 | https://orcid.org/0009-0007-8482-4144 |
| author_facet | https://orcid.org/0009-0007-8482-4144 Magi, María S. de Lafuente, Yanina Quarta, Eride Palena, María C. Ardiles, Perla del R. Páez, Paulina L. Sonvico, Fabio Buttini, Francesca Jimenez Kairuz, Alvaro F. |
| author_sort | Magi, María S. |
| collection | Repositorio Digital Universitario |
| description | Impact Factor: 4.9 (2023). 5-Year Impact Factor: 5.5 (2023).
Se publicó como preprint en: https://www.preprints.org/manuscript/202402.0587/v1 |
| format | info:eu-repo/semantics/publishedVersion |
| id | rdu-unc.552768 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2024 |
| publisher | Academic Editor: Vivek Verma |
| record_format | dspace |
| spelling | rdu-unc.5527682024-07-19T06:23:21Z Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis Magi, María S. de Lafuente, Yanina Quarta, Eride Palena, María C. Ardiles, Perla del R. Páez, Paulina L. Sonvico, Fabio Buttini, Francesca Jimenez Kairuz, Alvaro F. https://orcid.org/0009-0007-8482-4144 https://orcid.org/0000-0003-0215-2350 https://orcid.org/0009-0004-8719-5935 https://orcid.org/0000-0003-4836-4842 https://orcid.org/0000-0001-7372-1456 https://orcid.org/0000-0002-4472-4823 https://orcid.org/0000-0003-1659-7983 Inhalable vancomycin Cystic fibrosis Polyelectrolyte–drug complex Hyaluronic acid Pulmonary infection Impact Factor: 4.9 (2023). 5-Year Impact Factor: 5.5 (2023). Se publicó como preprint en: https://www.preprints.org/manuscript/202402.0587/v1 info:eu-repo/semantics/publishedVersion Fil: Magi, María S. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Magi, María S. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: de Lafuente, Yanina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: de Lafuente, Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Quarta, Eride. University of Parma. Food and Drug Department; Italy. Fil: Palena, María C. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Palena, María C. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Ardiles, Perla del R. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Ardiles, Perla del R. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Páez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Páez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Sonvico, Fabio. University of Parma. Food and Drug Department; Italy. Fil: , Buttini, Francesca. University of Parma. Food and Drug Department; Italy. Fil: Jimenez Kairuz, Alvaro F. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Jimenez Kairuz, Alvaro F. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Polyelectrolyte–drug complexes are interesting alternatives to improve unfavorable drug properties. Vancomycin (VAN) is an antimicrobial used in the treatment of methicillin-resistant Staphylococcus aureus pulmonary infections in patients with cystic fibrosis. It is generally administered intravenously with a high incidence of adverse side effects, which could be reduced by intrapulmonary administration. Currently, there are no commercially available inhalable formulations containing VAN. Thus, the present work focuses on the preparation and characterization of an ionic complex between hyaluronic acid (HA) and VAN with potential use in inhalable formulations. A particulate–solid HA-VAN25 complex was obtained by spray drying from an aqueous dispersion. FTIR spectroscopy and thermal analysis confirmed the ionic interaction between HA and VAN, while an amorphous diffraction pattern was observed by X-ray. The powder density, geometric size and morphology showed the suitable aerosolization and aerodynamic performance of the powder, indicating its capability of reaching the deep lung. An in vitro extended-release profile of VAN from the complex was obtained, exceeding 24 h. Microbiological assays against methicillin-resistant and -sensitive reference strains of Staphylococcus aureus showed that VAN preserves its antibacterial efficacy. In conclusion, HA-VAN25 exhibited interesting properties for the development of inhalable formulations with potential efficacy and safety advantages over conventional treatment. info:eu-repo/semantics/publishedVersion Fil: Magi, María S. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Magi, María S. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: de Lafuente, Yanina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: de Lafuente, Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Quarta, Eride. University of Parma. Food and Drug Department; Italy. Fil: Palena, María C. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Palena, María C. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Ardiles, Perla del R. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Ardiles, Perla del R. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Páez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Páez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Sonvico, Fabio. University of Parma. Food and Drug Department; Italy. Fil: , Buttini, Francesca. University of Parma. Food and Drug Department; Italy. Fil: Jimenez Kairuz, Alvaro F. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Jimenez Kairuz, Alvaro F. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. 2024-07-18T23:26:43Z 2024-07-18T23:26:43Z 2024-03-22 article Magi, M.S.; de Lafuente, Y.; Quarta, E.; Palena, M.C.; Ardiles, P.d.R.; Páez, P.L.; Sonvico, F.; Buttini, F.; Jimenez-Kairuz, A.F. Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis. Pharmaceutics 2024, 16, 436. https://doi.org/10.3390/ pharmaceutics16040436 http://hdl.handle.net/11086/552768 1999-4923 https://www.mdpi.com/1999-4923/16/4/436 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11054002/ doi.org/10.3390/pharmaceutics16040436 eng Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Academic Editor: Vivek Verma |
| spellingShingle | Inhalable vancomycin Cystic fibrosis Polyelectrolyte–drug complex Hyaluronic acid Pulmonary infection Magi, María S. de Lafuente, Yanina Quarta, Eride Palena, María C. Ardiles, Perla del R. Páez, Paulina L. Sonvico, Fabio Buttini, Francesca Jimenez Kairuz, Alvaro F. Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis |
| title | Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis |
| title_full | Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis |
| title_fullStr | Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis |
| title_full_unstemmed | Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis |
| title_short | Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis |
| title_sort | novel dry hyaluronic acid vancomycin complex powder for inhalation useful in pulmonary infections associated with cystic fibrosis |
| topic | Inhalable vancomycin Cystic fibrosis Polyelectrolyte–drug complex Hyaluronic acid Pulmonary infection |
| url | http://hdl.handle.net/11086/552768 https://www.mdpi.com/1999-4923/16/4/436 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11054002/ |
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