Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic
Impact Factor: 3.4
| Main Authors: | , , |
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| Format: | info:eu-repo/semantics/publishedVersion |
| Language: | eng |
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2024
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| Online Access: | http://hdl.handle.net/11086/552767 https://www.cell.com/heliyon/fulltext/S2405-8440(24)01635-9#%20 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864972/ |
| _version_ | 1806012164192862208 |
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| author | Scolari, Ivana Romina Paez, Paulina L. Granero, Gladys Ester |
| author2 | https://orcid.org/0009-0004-0570-7053 |
| author_facet | https://orcid.org/0009-0004-0570-7053 Scolari, Ivana Romina Paez, Paulina L. Granero, Gladys Ester |
| author_sort | Scolari, Ivana Romina |
| collection | Repositorio Digital Universitario |
| description | Impact Factor: 3.4 |
| format | info:eu-repo/semantics/publishedVersion |
| id | rdu-unc.552767 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2024 |
| record_format | dspace |
| spelling | rdu-unc.5527672024-07-19T23:57:49Z Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic Scolari, Ivana Romina Paez, Paulina L. Granero, Gladys Ester https://orcid.org/0009-0004-0570-7053 https://orcid.org/0000-0003-4836-4842 https://orcid.org/0000-0003-2142-1675 Gentamicin Zinc oxide nanoparticles (ZnO NPs) Synergic bactericidal activity Reactive oxygen species (ROS) Impact Factor: 3.4 info:eu-repo/semantics/publishedVersion Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina. Gentamicin (GEN), a widely used broad-spectrum antibiotic, faces challenges amid the global emergency of antimicrobial resistance. This study aimed to explore the synergistic effects of zinc oxide nanoparticles (ZnO NPs) in combination with GEN on the bactericidal activity against various bacterial strains. Results showed ZnO NPs with MICs ranging from 0.002 to 1.5 μg/mL, while the precursor salt displayed a MIC range of 48.75–1560 μg/mL. Chitosan (CS)-capped ZnO NPs exhibited even lower MICs than their uncapped counterparts, with the CS-capped synthesized ZnO NPs demonstrating the lowest values. Minimal bactericidal concentrations (MBC) aligned with MIC trends. Combinations of CS-capped synthesized ZnO NPs and GEN proved highly effective, inhibiting bacterial growth at significantly lower concentrations than GEN or ZnO NPs alone. This phenomenon may be attributed to the conformation of CS on the ZnO NPs' surface, enhancing the positive particle surface charge. This possibly facilitates a more effective interaction between ZnO NPs and microorganisms, leading to increased accumulation of zinc and GEN within bacterial cells and an overproduction of reactive oxygen species (ROS). It's crucial to note that, while this study did not specifically involve resistant strains, its primary focus remains on enhancing the overall antimicrobial activity of gentamicin. The research aims to contribute to addressing the global challenge of antimicrobial resistance, recognizing the urgent need for effective strategies to combat this critical issue. The findings, particularly the observed synergy between ZnO NPs and GEN, hold significant implications for repositioning the first-line antibiotic GEN. info:eu-repo/semantics/publishedVersion Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Scolari, Ivana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Paez, Paulina L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Paez, Paulina L. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Granero, Gladys Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica; Argentina. 2024-07-18T21:49:02Z 2024-07-18T21:49:02Z 2024-02-15 article Scolari, I. R., Páez, P. L., & Granero, G. E. (2024). Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic. Heliyon, 10(3). http://hdl.handle.net/11086/552767 2405-8440 https://www.cell.com/heliyon/fulltext/S2405-8440(24)01635-9#%20 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864972/ doi.org/10.1016/j.heliyon.2024.e25604 eng Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spellingShingle | Gentamicin Zinc oxide nanoparticles (ZnO NPs) Synergic bactericidal activity Reactive oxygen species (ROS) Scolari, Ivana Romina Paez, Paulina L. Granero, Gladys Ester Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic |
| title | Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic |
| title_full | Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic |
| title_fullStr | Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic |
| title_full_unstemmed | Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic |
| title_short | Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic |
| title_sort | synergistic bactericidal combinations between gentamicin and chitosan capped zno nanoparticles a promising strategy for repositioning this first line antibiotic |
| topic | Gentamicin Zinc oxide nanoparticles (ZnO NPs) Synergic bactericidal activity Reactive oxygen species (ROS) |
| url | http://hdl.handle.net/11086/552767 https://www.cell.com/heliyon/fulltext/S2405-8440(24)01635-9#%20 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864972/ |
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