Interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein for optimal immunometabolic profiling of the lifestyle-related cardiorenal risk
Fil: Marchiori, Georgina Noel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Secretaría de Graduados en Ciencias de la Salud; Argentina.
Main Authors: | , , , , , |
---|---|
Other Authors: | |
Format: | info:eu-repo/semantics/publishedVersion |
Language: | eng |
Published: |
2024
|
Subjects: | |
Online Access: | http://hdl.handle.net/11086/552705 |
_version_ | 1806011984286580736 |
---|---|
author | Marchiori, Georgina Noel Defagó, María Daniela Baraquet, María Lucía Del Rosso, Sebastián Perovic, Nilda Raquel Soria, Elio Andrés |
author2 | https://orcid.org/0000-0001-8633-9598 |
author_facet | https://orcid.org/0000-0001-8633-9598 Marchiori, Georgina Noel Defagó, María Daniela Baraquet, María Lucía Del Rosso, Sebastián Perovic, Nilda Raquel Soria, Elio Andrés |
author_sort | Marchiori, Georgina Noel |
collection | Repositorio Digital Universitario |
description | Fil: Marchiori, Georgina Noel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Secretaría de Graduados en Ciencias de la Salud; Argentina. |
format | info:eu-repo/semantics/publishedVersion |
id | rdu-unc.552705 |
institution | Universidad Nacional de Cordoba |
language | eng |
publishDate | 2024 |
record_format | dspace |
spelling | rdu-unc.5527052024-07-12T06:20:54Z Interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein for optimal immunometabolic profiling of the lifestyle-related cardiorenal risk Marchiori, Georgina Noel Defagó, María Daniela Baraquet, María Lucía Del Rosso, Sebastián Perovic, Nilda Raquel Soria, Elio Andrés https://orcid.org/0000-0001-8633-9598 https://orcid.org/0000-0002-8878-3067 https://orcid.org/0000-0002-7730-0816 https://orcid.org/0000-0003-2572-5887 https://orcid.org/0000-0003-4264-2610 https://orcid.org/0000-0003-2373-2493 Cardio-renal syndrome Cardiovascular system Clinical laboratory techniques Inflammation mediators Kidney Latent class analysis info:eu-repo/semantics/publishedVersion Fil: Marchiori, Georgina Noel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Secretaría de Graduados en Ciencias de la Salud; Argentina. Fil: Defagó, Daniela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Nutrición; Argentina. Fil: Defagó, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Baraquet, Lucía. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Nutrición; Argentina. Fil: Del Rosso, Sebastián. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Del Rosso, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Perovic, Nilda Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Nutrición; Argentina. Fil: Baraquet, María Lucía.Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Soria, Elio Andrés. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Biología Celular; Argentina Fil: Soria, Elio Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Objectives. The present study aimed to identify optimal inflammatory biomarkers involved in cardiorenal risk in response to major lifestyle factors. Methods. One hundred and twenty-nine adults aged 35–77 years participated voluntarily from 2017 to 2019 (Córdoba, Argentina) in a cross-sectional study to collect sociodemographic, clinical, and lifestyle data. Blood biomarkers (different cytokines, monocyte chemoattractant protein-1 [MCP-1], and high-sensitivity C-reactive protein [hs-CRP]) were measured using standard methods and then evaluated by principal component analysis and structural equation modeling (SEM) according to Mediterranean diet adherence, physical activity level, and waist circumference, while cardiorenal risk involved blood diastolic pressure, HDL-cholesterol, triacylglycerols, creatinine, and glycosylated hemoglobin. Results. A principal component included TNF-α (tumor necrosis factor-alpha), IL-8 (interleukin-8), IL-6 (interleukin-6), hs-CRP, and MCP-1, with absolute rotated factor loadings >0.10. SEM showed that IL-6 (β=0.38, 95 % IC=0.08–0.68), hs-CRP (β=0.33, 95 % IC=0.17–0.48), and TNF-α (β=0.22, 95 % IC=0.11–0.32) were the mediators that better explained an inflammatory profile positively related to waist circumference (β=0.77, 95 % IC=0.61–0.94). Moreover, this profile was associated with an increased cardiorenal risk (β=0.78, 95 % IC=0.61–0.94), which was well-defined by the variable used. Conclusions Immune mediators are key elements in profiling the cardiorenal risk associated with lifestyle factors, for which the combination of hs-CRP, IL-6, and TNF-α has emerged as a robust indicator. This work reaffirms the need for biomarker optimization for early diagnosis and risk assessment. info:eu-repo/semantics/publishedVersion Fil: Marchiori, Georgina Noel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Secretaría de Graduados en Ciencias de la Salud; Argentina. Fil: Defagó, Daniela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Nutrición; Argentina. Fil: Defagó, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Baraquet, Lucía. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Nutrición; Argentina. Fil: Del Rosso, Sebastián. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Del Rosso, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Perovic, Nilda Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Nutrición; Argentina. Fil: Baraquet, María Lucía.Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Soria, Elio Andrés. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Biología Celular; Argentina Fil: Soria, Elio Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. 2024-07-11T19:31:35Z 2024-07-11T19:31:35Z 2024-01-01 article Marchiori, G., Defagó, M., Baraquet, M., Del Rosso, S., Perovic, N. & Soria, E. (2024). Interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein for optimal immunometabolic profiling of the lifestyle-related cardiorenal risk. Diagnosis, 11(1), 82-90. https://doi.org/10.1515/dx-2023-0159 http://hdl.handle.net/11086/552705 2194-802X eng Attribution- 4.0 International http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Cardio-renal syndrome Cardiovascular system Clinical laboratory techniques Inflammation mediators Kidney Latent class analysis Marchiori, Georgina Noel Defagó, María Daniela Baraquet, María Lucía Del Rosso, Sebastián Perovic, Nilda Raquel Soria, Elio Andrés Interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein for optimal immunometabolic profiling of the lifestyle-related cardiorenal risk |
title | Interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein for optimal immunometabolic profiling of the lifestyle-related cardiorenal risk |
title_full | Interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein for optimal immunometabolic profiling of the lifestyle-related cardiorenal risk |
title_fullStr | Interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein for optimal immunometabolic profiling of the lifestyle-related cardiorenal risk |
title_full_unstemmed | Interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein for optimal immunometabolic profiling of the lifestyle-related cardiorenal risk |
title_short | Interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein for optimal immunometabolic profiling of the lifestyle-related cardiorenal risk |
title_sort | interleukin 6 tumor necrosis factor α and high sensitivity c reactive protein for optimal immunometabolic profiling of the lifestyle related cardiorenal risk |
topic | Cardio-renal syndrome Cardiovascular system Clinical laboratory techniques Inflammation mediators Kidney Latent class analysis |
url | http://hdl.handle.net/11086/552705 |
work_keys_str_mv | AT marchiorigeorginanoel interleukin6tumornecrosisfactoraandhighsensitivitycreactiveproteinforoptimalimmunometabolicprofilingofthelifestylerelatedcardiorenalrisk AT defagomariadaniela interleukin6tumornecrosisfactoraandhighsensitivitycreactiveproteinforoptimalimmunometabolicprofilingofthelifestylerelatedcardiorenalrisk AT baraquetmarialucia interleukin6tumornecrosisfactoraandhighsensitivitycreactiveproteinforoptimalimmunometabolicprofilingofthelifestylerelatedcardiorenalrisk AT delrossosebastian interleukin6tumornecrosisfactoraandhighsensitivitycreactiveproteinforoptimalimmunometabolicprofilingofthelifestylerelatedcardiorenalrisk AT perovicnildaraquel interleukin6tumornecrosisfactoraandhighsensitivitycreactiveproteinforoptimalimmunometabolicprofilingofthelifestylerelatedcardiorenalrisk AT soriaelioandres interleukin6tumornecrosisfactoraandhighsensitivitycreactiveproteinforoptimalimmunometabolicprofilingofthelifestylerelatedcardiorenalrisk |