Ecotoxicological Characterization of Lithium as a “Timebomb” in Aquatic Systems: Tadpoles of the South American Toad Rhinellaarenarum (Hensel, 1867) as Model Organisms
Impact Factor 3.9
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2024
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Online Access: | http://hdl.handle.net/11086/552610 https://www.mdpi.com/2305-6304/12/3/176 https://pubmed.ncbi.nlm.nih.gov/38535909/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10974550/ https://doi.org/10.3390/ |
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author | Peltzer, Paola M. Cuzziol Boccioni, Ana P. Attademo, Andrés M. Simoniello, María F. Lener, Germán Lajmanovich, Rafael C. |
author2 | https://orcid.org/0000-0002-8533-1129 |
author_facet | https://orcid.org/0000-0002-8533-1129 Peltzer, Paola M. Cuzziol Boccioni, Ana P. Attademo, Andrés M. Simoniello, María F. Lener, Germán Lajmanovich, Rafael C. |
author_sort | Peltzer, Paola M. |
collection | Repositorio Digital Universitario |
description | Impact Factor 3.9 |
format | info:eu-repo/semantics/publishedVersion |
id | rdu-unc.552610 |
institution | Universidad Nacional de Cordoba |
language | eng |
publishDate | 2024 |
record_format | dspace |
spelling | rdu-unc.5526102024-07-08T06:22:17Z Ecotoxicological Characterization of Lithium as a “Timebomb” in Aquatic Systems: Tadpoles of the South American Toad Rhinellaarenarum (Hensel, 1867) as Model Organisms Peltzer, Paola M. Cuzziol Boccioni, Ana P. Attademo, Andrés M. Simoniello, María F. Lener, Germán Lajmanovich, Rafael C. https://orcid.org/0000-0002-8533-1129 https://orcid.org/0000-0002-8498-7134 https://orcid.org/0000-0002-1315-9278 https://orcid.org/0000-0002-5630-9117 Li Evironmental risk Tadpoles Aquatic contamination Lithium Impact Factor 3.9 info:eu-repo/semantics/publishedVersion Fil: Peltzer, Paola M. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Ecotoxicología, Argentina. Fil: Peltzer, Paola M. Consejo Nacional de Investigaciones Científicas Técnicas, Argentina. Fil: Cuzziol Boccioni, Ana P. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Ecotoxicología, Argentina. Fil: Cuzziol Boccioni, Ana P. Consejo Nacional de Investigaciones Científicas Técnicas, Argentina. Fil: Attademo, Andrés M. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Ecotoxicología, Argentina. Fil: Attademo, Andrés M. Consejo Nacional de Investigaciones Científicas Técnicas, Argentina. Fil: Simoniello, María F. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Toxicología, Farmacología y Bioquímica Legal, Argentina. Fil: Lener, Germán. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Teórica y Computacional, Argentina. Fil: Lener, Germán. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Físico-Química de Córdoba, Argentina. Fil: Lajmanovich, Rafael C. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Ecotoxicología, Argentina. Fil: Lajmanovich, Rafael C. Consejo Nacional de Investigaciones Científicas Técnicas, Argentina. The aim of this study was to evaluate the acute lethality and chronic sublethal effects of lithium (Li) on Rhinella arenarum tadpoles as model organisms. First a 96 h toxicity assay was performed by exposing tadpoles to Li concentrations from 44.08 to 412.5 mg L−1 to estimate the mortality, and lethal and sublethal effects. Another bioassay was carried out by exposing tadpoles to two environmentally relevant Li concentrations (2.5 and 20 mg L−1) for one and two weeks. The sublethal effects of Li on tadpoles were evaluated by analyzing biochemical, genotoxic, and physiological biomarkers. The mortality in Li-exposed tadpoles increased over time. The median lethal concentration (LC50) ranged from 319.52 (281.21–363.05) mg L−1 at 48 h to 66.92 (52.76–84.89) mg L−1 at 96 h. Exposure to Li at 2.5 and 20 mg L−1 induced alterations in enzymes related to detoxification, antioxidant, and hepatic mechanisms, endocrine disruption of thyroid hormones, genotoxicity, and effects on the physiology of the heart and gastrointestinal systems. Tadpoles exposed to the highest concentration in the chronic bioassay (20 mg L−1 Li), which is the concentration commonly recorded in Li mining sites, showed significant mortality after one week of exposure. These results warn about the high ecotoxicological risk of Li as a contaminant of emerging concern for amphibians. info:eu-repo/semantics/publishedVersion Fil: Peltzer, Paola M. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Ecotoxicología, Argentina. Fil: Peltzer, Paola M. Consejo Nacional de Investigaciones Científicas Técnicas, Argentina. Fil: Cuzziol Boccioni, Ana P. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Ecotoxicología, Argentina. Fil: Cuzziol Boccioni, Ana P. Consejo Nacional de Investigaciones Científicas Técnicas, Argentina. Fil: Attademo, Andrés M. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Ecotoxicología, Argentina. Fil: Attademo, Andrés M. Consejo Nacional de Investigaciones Científicas Técnicas, Argentina. Fil: Simoniello, María F. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Toxicología, Farmacología y Bioquímica Legal, Argentina. Fil: Lener, Germán. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Teórica y Computacional, Argentina. Fil: Lener, Germán. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Físico-Química de Córdoba, Argentina. Fil: Lajmanovich, Rafael C. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Ecotoxicología, Argentina. Fil: Lajmanovich, Rafael C. Consejo Nacional de Investigaciones Científicas Técnicas, Argentina. 2024-07-07T22:53:05Z 2024-07-07T22:53:05Z 2024-02-25 article Peltzer, P.M.; Cuzziol Boccioni, A.P.; Attademo, A.M.; Simoniello, M.F.; Lener, G.; Lajmanovich, R.C. Ecotoxicological Characterization of Lithium as a “Timebomb” in Aquatic Systems: Tadpoles of the South American Toad Rhinella arenarum (Hensel, 1867) as Model Organisms. Toxics 2024, 12, 176. https://doi.org/10.3390/ toxics12030176 http://hdl.handle.net/11086/552610 2305-6304 https://www.mdpi.com/2305-6304/12/3/176 https://pubmed.ncbi.nlm.nih.gov/38535909/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10974550/ https://doi.org/10.3390/ eng Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Li Evironmental risk Tadpoles Aquatic contamination Lithium Peltzer, Paola M. Cuzziol Boccioni, Ana P. Attademo, Andrés M. Simoniello, María F. Lener, Germán Lajmanovich, Rafael C. Ecotoxicological Characterization of Lithium as a “Timebomb” in Aquatic Systems: Tadpoles of the South American Toad Rhinellaarenarum (Hensel, 1867) as Model Organisms |
title | Ecotoxicological Characterization of Lithium as a “Timebomb” in Aquatic Systems: Tadpoles of the South American Toad Rhinellaarenarum (Hensel, 1867) as Model Organisms |
title_full | Ecotoxicological Characterization of Lithium as a “Timebomb” in Aquatic Systems: Tadpoles of the South American Toad Rhinellaarenarum (Hensel, 1867) as Model Organisms |
title_fullStr | Ecotoxicological Characterization of Lithium as a “Timebomb” in Aquatic Systems: Tadpoles of the South American Toad Rhinellaarenarum (Hensel, 1867) as Model Organisms |
title_full_unstemmed | Ecotoxicological Characterization of Lithium as a “Timebomb” in Aquatic Systems: Tadpoles of the South American Toad Rhinellaarenarum (Hensel, 1867) as Model Organisms |
title_short | Ecotoxicological Characterization of Lithium as a “Timebomb” in Aquatic Systems: Tadpoles of the South American Toad Rhinellaarenarum (Hensel, 1867) as Model Organisms |
title_sort | ecotoxicological characterization of lithium as a timebomb in aquatic systems tadpoles of the south american toad rhinellaarenarum hensel 1867 as model organisms |
topic | Li Evironmental risk Tadpoles Aquatic contamination Lithium |
url | http://hdl.handle.net/11086/552610 https://www.mdpi.com/2305-6304/12/3/176 https://pubmed.ncbi.nlm.nih.gov/38535909/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10974550/ https://doi.org/10.3390/ |
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