Magnetic hybrid nanomaterial based on a natural polymer and an amino acid as pH/temperature dual-responsive nanoplatform for the delivery of tamoxifen
Impact Factor: 4.1
Main Authors: | , , , , , , , |
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Format: | info:eu-repo/semantics/publishedVersion |
Language: | eng |
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2024
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Online Access: | http://hdl.handle.net/11086/552608 https://www.frontiersin.org/journals/nanotechnology/articles/10.3389/fnano.2024.1384605/full https://doi.org/10.3389/fnano.2024.1384605 |
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author | Torres, Jazmín Cadena Castro, Diego Ancarani, Rosario Bruvera, Ignacio Zélis Mendoza, Pedro Martín, Sandra E. García, Mónica C. Uberman, Paula M. |
author2 | https://orcid.org/0000-0002-3411-4810 |
author_facet | https://orcid.org/0000-0002-3411-4810 Torres, Jazmín Cadena Castro, Diego Ancarani, Rosario Bruvera, Ignacio Zélis Mendoza, Pedro Martín, Sandra E. García, Mónica C. Uberman, Paula M. |
author_sort | Torres, Jazmín |
collection | Repositorio Digital Universitario |
description | Impact Factor: 4.1 |
format | info:eu-repo/semantics/publishedVersion |
id | rdu-unc.552608 |
institution | Universidad Nacional de Cordoba |
language | eng |
publishDate | 2024 |
record_format | dspace |
spelling | rdu-unc.5526082024-07-08T06:22:19Z Magnetic hybrid nanomaterial based on a natural polymer and an amino acid as pH/temperature dual-responsive nanoplatform for the delivery of tamoxifen Torres, Jazmín Cadena Castro, Diego Ancarani, Rosario Bruvera, Ignacio Zélis Mendoza, Pedro Martín, Sandra E. García, Mónica C. Uberman, Paula M. https://orcid.org/0000-0002-3411-4810 https://orcid.org/0000-0002-7868-8912 https://orcid.org/0000-0002-0411-8300 https://orcid.org/0000-0002-1943-4891 https://orcid.org/0000-0003-1211-9968 Stimuli-responsive nanocarriers Hyaluronic acid L-cysteine Controlled drug release Cancer nanomedicine Impact Factor: 4.1 info:eu-repo/semantics/publishedVersion Fil: Torres, Jazmín. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas, Argentina. Fil: Torres, Jazmín. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, Argentina. Fil: Cadena Castro, Diego. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica, Argentina. Fil: Cadena Castro, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina. Fil: Ancarani, Rosario. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas, Argentina. Fil: Bruvera, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física La Plata, Buenos Aires, Argentina. Fil: Zélis Mendoza, Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física La Plata, Buenos Aires, Argentina. Fil: Martín, Sandra E. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica, Argentina. Fil: Martín, Sandra E. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina. Fil: García, Mónica C. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas, Argentina. Fil: García, Mónica C. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, Argentina. Fil: Uberman Paula M. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica, Argentina. Fil: Uberman Paula M. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina. Magnetic hybrid nanomaterials offer promising properties for the advancement of nanoplatforms in cancer nanomedicine, particularly in drug delivery applications. These nanoplatforms can effectively respond to various stimuli present at the tumor site, such as pH and temperature fluctuations, allowing for controlled and triggered release of therapeutic payloads. In this study, we present a straightforward methodology for the synthesis of stable hybrid magnetic nanoplatforms (HMNP) based on Fe3O4 nanoparticles, L-cysteine (L-Cys), and hyaluronic acid (HA) as key constituents for the delivery of tamoxifen (TMX). The synthesized superparamagnetic HMNP, Fe3O4-L-Cys-HA, with a size of 11 nm, was successfully loaded with TMX. The incorporation of L-Cys showed superior interaction with the surface of Fe3O4 nanoparticles compared to other L-Cys derivatives explored as ligands. Consequently, L-Cys was selected for further functionalization with HA, providing the HMNP with active targeting properties toward CD44-overexpressed receptors. High loading efficiency of TMX (75%) was achieved via electrostatic interaction between the carboxylate groups exposed by the HMNP and the ammonium group of the TMX side chain. Efficient control in the TMX release towards different receptor media was observed. Notably, the release of TMX from HMNP-TMX was triggered under acidic pH and hyperthermia conditions, showcasing its responsiveness to both stimuli. Furthermore, enhanced anticancer activity of TMX against MDA-MB-231 breast cancer cells was observed when loaded into HMNP (IC50 almost 3-fold lower for HMNP-TMX compared to free TMX), indicating improved cell uptake of TMX-loaded HMNP in comparison to the free drug. Overall, pH/temperature dual-sensitive HMNP demonstrates promising potential as a nanoplatform for cancer nanomedicine, with prospects for magnetic hyperthermia therapy. info:eu-repo/semantics/publishedVersion Fil: Torres, Jazmín. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas, Argentina. Fil: Torres, Jazmín. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, Argentina. Fil: Cadena Castro, Diego. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica, Argentina. Fil: Cadena Castro, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina. Fil: Ancarani, Rosario. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas, Argentina. Fil: Bruvera, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física La Plata, Buenos Aires, Argentina. Fil: Zélis Mendoza, Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física La Plata, Buenos Aires, Argentina. Fil: Martín, Sandra E. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica, Argentina. Fil: Martín, Sandra E. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina. Fil: García, Mónica C. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas, Argentina. Fil: García, Mónica C. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, Argentina. Fil: Uberman Paula M. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica, Argentina. Fil: Uberman Paula M. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina. 2024-07-07T20:52:40Z 2024-07-07T20:52:40Z 2024-04-12 article Torres J, Cadena Castro D, Ancarani R, Bruvera I, Mendoza Zélis P, Martín SE, García MC and Uberman PM (2024), Magnetic hybrid nanomaterial based on a natural polymer and an amino acid as pH/temperature dual-responsive nanoplatform for the delivery of tamoxifen. Front. Nanotechnol. 6:1384605. doi: 10.3389/fnano.2024.1384605 http://hdl.handle.net/11086/552608 2673-3013 https://www.frontiersin.org/journals/nanotechnology/articles/10.3389/fnano.2024.1384605/full https://doi.org/10.3389/fnano.2024.1384605 eng Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Stimuli-responsive nanocarriers Hyaluronic acid L-cysteine Controlled drug release Cancer nanomedicine Torres, Jazmín Cadena Castro, Diego Ancarani, Rosario Bruvera, Ignacio Zélis Mendoza, Pedro Martín, Sandra E. García, Mónica C. Uberman, Paula M. Magnetic hybrid nanomaterial based on a natural polymer and an amino acid as pH/temperature dual-responsive nanoplatform for the delivery of tamoxifen |
title | Magnetic hybrid nanomaterial based on a natural polymer and an amino acid as pH/temperature dual-responsive nanoplatform for the delivery of tamoxifen |
title_full | Magnetic hybrid nanomaterial based on a natural polymer and an amino acid as pH/temperature dual-responsive nanoplatform for the delivery of tamoxifen |
title_fullStr | Magnetic hybrid nanomaterial based on a natural polymer and an amino acid as pH/temperature dual-responsive nanoplatform for the delivery of tamoxifen |
title_full_unstemmed | Magnetic hybrid nanomaterial based on a natural polymer and an amino acid as pH/temperature dual-responsive nanoplatform for the delivery of tamoxifen |
title_short | Magnetic hybrid nanomaterial based on a natural polymer and an amino acid as pH/temperature dual-responsive nanoplatform for the delivery of tamoxifen |
title_sort | magnetic hybrid nanomaterial based on a natural polymer and an amino acid as ph temperature dual responsive nanoplatform for the delivery of tamoxifen |
topic | Stimuli-responsive nanocarriers Hyaluronic acid L-cysteine Controlled drug release Cancer nanomedicine |
url | http://hdl.handle.net/11086/552608 https://www.frontiersin.org/journals/nanotechnology/articles/10.3389/fnano.2024.1384605/full https://doi.org/10.3389/fnano.2024.1384605 |
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