An Alternative Pathway for the Synthesis of Glycerol Phenylbutyrate
Impact Factor: 2.1
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | info:eu-repo/semantics/publishedVersion |
| Language: | eng |
| Published: |
2024
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/11086/552607 https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202304021 https://chemistry-europe.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fslct.202304021&file=slct202304021-sup-0001-misc_information.pdf https://doi.org/10.1002/slct.202304021 |
| _version_ | 1806012160273285120 |
|---|---|
| author | Suchetti, Laura Foray, Gabriela Tempesti, Tomas C. Ferrayoli, Carlos |
| author2 | https://orcid.org/0009-0006-7194-2427 |
| author_facet | https://orcid.org/0009-0006-7194-2427 Suchetti, Laura Foray, Gabriela Tempesti, Tomas C. Ferrayoli, Carlos |
| author_sort | Suchetti, Laura |
| collection | Repositorio Digital Universitario |
| description | Impact Factor: 2.1 |
| format | info:eu-repo/semantics/publishedVersion |
| id | rdu-unc.552607 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2024 |
| record_format | dspace |
| spelling | rdu-unc.5526072024-07-08T06:22:16Z An Alternative Pathway for the Synthesis of Glycerol Phenylbutyrate Suchetti, Laura Foray, Gabriela Tempesti, Tomas C. Ferrayoli, Carlos https://orcid.org/0009-0006-7194-2427 https://orcid.org/0000-0003-3374-2273 Synthesis of Glycerol Phenylbutyrate Pediatric patients Hyperammonemia Impact Factor: 2.1 info:eu-repo/semantics/publishedVersion Fil: Suchetti, Laura. Ministerio de Ciencia y Tecnología de la Provincia de Córdoba. Departamento de Química, Argentina. Fil: Foray, Gabriela. Ministerio de Ciencia y Tecnología de la Provincia de Córdoba. Departamento de Química, Argentina. Fil: Tempesti Tomas C. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica, Argentina. Fil: Tempesti Tomas C. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Físico-Química de Córdoba, Argentina. Fil: Ferrayoli, Carlos. Ministerio de Ciencia y Tecnología de la Provincia de Córdoba. Departamento de Química, Argentina. Hyperammonemia is a life-threatening condition which can affect patients at any age. In pediatric patients, hyperammonemia can be caused by various acquired or inherited disorders such as urea cycle deficiencies or organic acidemias. Glycerol phenylbutyrate (GPB) is an orphan drug used in the treatment of hyperammonemia. GPB is a triglyceride composed of three phenylbutyric acid (PBA) molecules esterified to a glycerol molecule, which is synthesized through the acyl chloride route using thionyl chloride as an acylating agent. In this work we have developed an alternative synthesis method to obtain GPB directly under ambient conditions and avoiding the use of chlorinated solvents. Moreover, the use of carbodiimides as coupling agents, instead of thionyl chloride, allowed the conversion to the GPB in higher yields and with higher purity, without the need for column purification. We present a methodology that allows the production of GPB in a simple, efficient and environmentally and human health friendly way. info:eu-repo/semantics/publishedVersion Fil: Suchetti, Laura. Ministerio de Ciencia y Tecnología de la Provincia de Córdoba. Departamento de Química, Argentina. Fil: Foray, Gabriela. Ministerio de Ciencia y Tecnología de la Provincia de Córdoba. Departamento de Química, Argentina. Fil: Tempesti Tomas C. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica, Argentina. Fil: Tempesti Tomas C. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Físico-Química de Córdoba, Argentina. Fil: Ferrayoli, Carlos. Ministerio de Ciencia y Tecnología de la Provincia de Córdoba. Departamento de Química, Argentina. 2024-07-07T18:42:49Z 2024-07-07T18:42:49Z 2024-01-22 article Suchetti, L., Foray, G., Tempesti, T. C., & Ferrayoli, C. (2024). An Alternative Pathway for the Synthesis of Glycerol Phenylbutyrate. ChemistrySelect, 9(4), e202304021. http://hdl.handle.net/11086/552607 2365-6549 https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202304021 https://chemistry-europe.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fslct.202304021&file=slct202304021-sup-0001-misc_information.pdf https://doi.org/10.1002/slct.202304021 eng Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spellingShingle | Synthesis of Glycerol Phenylbutyrate Pediatric patients Hyperammonemia Suchetti, Laura Foray, Gabriela Tempesti, Tomas C. Ferrayoli, Carlos An Alternative Pathway for the Synthesis of Glycerol Phenylbutyrate |
| title | An Alternative Pathway for the Synthesis of Glycerol Phenylbutyrate |
| title_full | An Alternative Pathway for the Synthesis of Glycerol Phenylbutyrate |
| title_fullStr | An Alternative Pathway for the Synthesis of Glycerol Phenylbutyrate |
| title_full_unstemmed | An Alternative Pathway for the Synthesis of Glycerol Phenylbutyrate |
| title_short | An Alternative Pathway for the Synthesis of Glycerol Phenylbutyrate |
| title_sort | alternative pathway for the synthesis of glycerol phenylbutyrate |
| topic | Synthesis of Glycerol Phenylbutyrate Pediatric patients Hyperammonemia |
| url | http://hdl.handle.net/11086/552607 https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202304021 https://chemistry-europe.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fslct.202304021&file=slct202304021-sup-0001-misc_information.pdf https://doi.org/10.1002/slct.202304021 |
| work_keys_str_mv | AT suchettilaura analternativepathwayforthesynthesisofglycerolphenylbutyrate AT foraygabriela analternativepathwayforthesynthesisofglycerolphenylbutyrate AT tempestitomasc analternativepathwayforthesynthesisofglycerolphenylbutyrate AT ferrayolicarlos analternativepathwayforthesynthesisofglycerolphenylbutyrate AT suchettilaura alternativepathwayforthesynthesisofglycerolphenylbutyrate AT foraygabriela alternativepathwayforthesynthesisofglycerolphenylbutyrate AT tempestitomasc alternativepathwayforthesynthesisofglycerolphenylbutyrate AT ferrayolicarlos alternativepathwayforthesynthesisofglycerolphenylbutyrate |