Angiotensin II-independent abnormal renal vascular reactivity during puromycin nephropathy
Fil: Juncos, Luis Isaias. Fundación J. Robert Cade; Argentina.
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | info:eu-repo/semantics/acceptedVersion |
| Language: | eng |
| Published: |
2024
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| Online Access: | http://hdl.handle.net/11086/552543 https://medandlife.org/ http://dx.doi.org/10.25122/jml-2023-0367 |
| _version_ | 1806012314246184960 |
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| author | Juncos, Luis Isaias Adeoye, Akinwunmi Oluwaseun Martin, Fernando Luis Juncos, Julio Pedro Baigorria, Sandra Teresita García, Néstor Horacio |
| author2 | https://orcid.org/0000-0002-3840-0419 |
| author_facet | https://orcid.org/0000-0002-3840-0419 Juncos, Luis Isaias Adeoye, Akinwunmi Oluwaseun Martin, Fernando Luis Juncos, Julio Pedro Baigorria, Sandra Teresita García, Néstor Horacio |
| author_sort | Juncos, Luis Isaias |
| collection | Repositorio Digital Universitario |
| description | Fil: Juncos, Luis Isaias. Fundación J. Robert Cade; Argentina. |
| format | info:eu-repo/semantics/acceptedVersion |
| id | rdu-unc.552543 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2024 |
| record_format | dspace |
| spelling | rdu-unc.5525432024-07-04T06:23:15Z Angiotensin II-independent abnormal renal vascular reactivity during puromycin nephropathy Juncos, Luis Isaias Adeoye, Akinwunmi Oluwaseun Martin, Fernando Luis Juncos, Julio Pedro Baigorria, Sandra Teresita García, Néstor Horacio https://orcid.org/0000-0002-3840-0419 https://orcid.org/0000-0002-2669-0607 https://orcid.org/0000-0002-3840-0419 Kidney Puromycin nephropathy Quinapril Sodium Glomerulonephritis info:eu-repo/semantics/acceptedVersion Fil: Juncos, Luis Isaias. Fundación J. Robert Cade; Argentina. Fil: Adeoye, Akinwunmi Oluwaseun. University Federal Oye-Ekiti. Department of Biochemistry; Nigeria. Fil: Adeoye, Akinwunmi Oluwaseun. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Martin, Fernando Luis. Fundación J. Robert Cade; Argentina. Fil: Juncos, Julio Pedro. Fundación J. Robert Cade; Argentina. Fil: Baigorria, Sandra Teresita. Fundación J. Robert Cade; Argentina. Fil: García, Néstor Horacio. Fundación J. Robert Cade; Argentina. Fil: García, Néstor Horacio. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina. Fil: García, Néstor Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Experimental glomerulonephritis results in hypertension that is sensitive to salt. Nevertheless, salt retention alone cannot explain the increase in blood pressure. Angiotensin antagonistic therapy reduces hypertension caused by puromycin amino nucleosides (PAN). We investigated the hypothesis that PAN modifies renal vascular reactivity through processes dependent on angiotensin. Long-Evans rats were given an intraperitoneal injection of either puromycin (150 mg/kg) or saline (controls). Group 1 was fed a normal sodium diet (NSD, n = 9). Group 2 was given 30 mg/L of quinapril (Q) in addition to NSD (NSD + Q; n = 6). Group 3 received a high sodium diet (HSD, n = 7), and Group 4 received HSD + Q (n = 7). Systolic blood pressure (SBP), plasma creatinine, proteinuria, and sodium balance were monitored for 12 days. On day 15, renal vascular reactivity was assessed by administering increasing doses of angiotensin II, acetylcholine (ACh), and sodium nitroprusside (SNP) directly into the renal artery. SBP progressively increased in all PAN groups. This increase in SBP was greater in the HSD groups and was not significantly altered by Q treatment. SBP increased by 22 ± 4% (NSD), 51 ± 5% (NSD + Q), 81 ± 10% (HSD), and 65 ± 8% (HSD + Q). The renal blood flow of PAN rats did not return to baseline despite their normal renal vasoconstrictor responses to angiotensin II. Additionally, they showed reduced renal vasodilator responses to SNP and Ach. The vasodilator responses to both vasodilators were surprisingly unaffected by the inhibition of the angiotensin-converting enzyme (ACE). Renal vasodilator responses to both endothelium-dependent and independent variables were reduced in early PAN-induced hypertension. We found that the angiotensin-mediated mechanism is not responsible for this altered renal vasoreactivity. info:eu-repo/semantics/acceptedVersion Fil: Juncos, Luis Isaias. Fundación J. Robert Cade; Argentina. Fil: Adeoye, Akinwunmi Oluwaseun. University Federal Oye-Ekiti. Department of Biochemistry; Nigeria. Fil: Adeoye, Akinwunmi Oluwaseun. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Martin, Fernando Luis. Fundación J. Robert Cade; Argentina. Fil: Juncos, Julio Pedro. Fundación J. Robert Cade; Argentina. Fil: Baigorria, Sandra Teresita. Fundación J. Robert Cade; Argentina. Fil: García, Néstor Horacio. Fundación J. Robert Cade; Argentina. Fil: García, Néstor Horacio. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina. Fil: García, Néstor Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. 2024-07-03T19:55:44Z 2024-07-03T19:55:44Z 2024-03-03 article García, N. H. (2024). Angiotensin II-independent abnormal renal vascular reactivity during puromycin nephropathy. JOURNAL of MEDICINE and LIFE, 17(3). http://hdl.handle.net/11086/552543 1844-3117 https://medandlife.org/ http://dx.doi.org/10.25122/jml-2023-0367 eng Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Kidney Puromycin nephropathy Quinapril Sodium Glomerulonephritis Juncos, Luis Isaias Adeoye, Akinwunmi Oluwaseun Martin, Fernando Luis Juncos, Julio Pedro Baigorria, Sandra Teresita García, Néstor Horacio Angiotensin II-independent abnormal renal vascular reactivity during puromycin nephropathy |
| title | Angiotensin II-independent abnormal renal vascular reactivity during puromycin nephropathy |
| title_full | Angiotensin II-independent abnormal renal vascular reactivity during puromycin nephropathy |
| title_fullStr | Angiotensin II-independent abnormal renal vascular reactivity during puromycin nephropathy |
| title_full_unstemmed | Angiotensin II-independent abnormal renal vascular reactivity during puromycin nephropathy |
| title_short | Angiotensin II-independent abnormal renal vascular reactivity during puromycin nephropathy |
| title_sort | angiotensin ii independent abnormal renal vascular reactivity during puromycin nephropathy |
| topic | Kidney Puromycin nephropathy Quinapril Sodium Glomerulonephritis |
| url | http://hdl.handle.net/11086/552543 https://medandlife.org/ http://dx.doi.org/10.25122/jml-2023-0367 |
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