Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function
Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.
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| Format: | conferenceObject |
| Language: | eng |
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2023
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| Online Access: | http://hdl.handle.net/11086/547217 |
| _version_ | 1801211462688964608 |
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| author | Kembro, Jackelyn Melissa |
| author_facet | Kembro, Jackelyn Melissa |
| author_sort | Kembro, Jackelyn Melissa |
| collection | Repositorio Digital Universitario |
| description | Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. |
| format | conferenceObject |
| id | rdu-unc.547217 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2023 |
| record_format | dspace |
| spelling | rdu-unc.5472172024-02-29T06:23:24Z Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function Kembro, Jackelyn Melissa Química biológica Redes mitocondriales Reactive oxygen species [ROS] Investigaciones biológicas Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina. The time-keeping properties bestowed by oscillatory behavior on functional rhythms represent an evolutionarily conserved trait in living systems. Mitochondrial networks function as timekeepers maximizing energetic output while tuning reactive oxygen species [ROS] within physiological levels compatible with signaling. In this work, we explore the potential for timekeeping functions dependent on mitochondrial dynamics with the validated two-compartment mitochondrial energetic-redox (ME-R) computational model, that takes into account (a) four main redox couples (NADH, NADPH, GSH, Trx(SH)2), (b) scavenging systems (glutathione, thioredoxin, SOD, catalase) distributed in matrix and extra-matrix compartments, and (c) transport of ROS species between them. Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina. Biofísica 2023-04-27T13:00:32Z 2023-04-27T13:00:32Z 2014 conferenceObject http://hdl.handle.net/11086/547217 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso |
| spellingShingle | Química biológica Redes mitocondriales Reactive oxygen species [ROS] Investigaciones biológicas Kembro, Jackelyn Melissa Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| title | Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| title_full | Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| title_fullStr | Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| title_full_unstemmed | Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| title_short | Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| title_sort | complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| topic | Química biológica Redes mitocondriales Reactive oxygen species [ROS] Investigaciones biológicas |
| url | http://hdl.handle.net/11086/547217 |
| work_keys_str_mv | AT kembrojackelynmelissa complexoscillatoryredoxdynamicswithsignalingpotentialattheedgebetweennormalandpathologicalmitochondrialfunction |