Individual differences predictive of ethanol-induced reinforcement and ethanol intake during adolescence
Fil: Pautassi, Ricardo Marcos. Universidad Nacional de Córdoba; Argentina.
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| Format: | conferenceObject |
| Language: | eng |
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2023
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| Online Access: | http://hdl.handle.net/11086/546703 |
| _version_ | 1811173509897912320 |
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| author | Pautassi, Ricardo Marcos |
| author_facet | Pautassi, Ricardo Marcos |
| author_sort | Pautassi, Ricardo Marcos |
| collection | Repositorio Digital Universitario |
| description | Fil: Pautassi, Ricardo Marcos. Universidad Nacional de Córdoba; Argentina. |
| format | conferenceObject |
| id | rdu-unc.546703 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2023 |
| record_format | dspace |
| spelling | rdu-unc.5467032024-09-19T20:49:41Z Individual differences predictive of ethanol-induced reinforcement and ethanol intake during adolescence Pautassi, Ricardo Marcos ADOLESCENT RAT ANXIETY ALCOHOL Fil: Pautassi, Ricardo Marcos. Universidad Nacional de Córdoba; Argentina. Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Likelihood of alcohol use disorders is greater in adolescence than in other developmental stages. Greater novelty-seeking, enhanced sensitivity to stress or to ethanol-induced appetitive effects, or lessened sensitivity to ethanol-induced sedation may underlie adolescent vulnerability to alcohol-related problems. The present work describes studies assessing susceptibility to ethanol reinforcement and intake in subpopulations of rats that differed in their innate levels of novelty seeking or anxiety patterns, or in their level of response to ethanol. In an early study we found that binge ethanol exposure early on adolescence enhanced ethanol intake and that adolescents exhibiting greater sensibility to the motor activating effects of binge ethanol administration were even more predispose to drink ethanol. Subsequent work indicated that the motor stimulating effect of ethanol and the facilitative effect of ethanol binge exposure on later ethanol intake are greater in adolescent than in adult rats. Moreover, enhanced level of exploration in an open-field at adolescence was associated with greater ethanol-induced conditioned place preference and reduced ethanol-induced conditioned taste aversion. Recent work indicated that adolescents exhibiting reduced exploration of the open arms of an elevated plus maze and higher anxiety response in a light-dark maze drank significantly more ethanol than counterparts with average levels of anxiety. Similar enhancement in ethanol intake was found in adolescents that had been chronically exposed to maternal deprivation. These results suggest that certain subpopulations of adolescents - those with innate or stress-induced high levels of anxiety, exacerbated novelty-seeking response or enhanced sensitivity to ethanol-induced psychomotor effects - may be at greater risk of elevated alcohol intake. http://www.lasbra.net/Abstracts%20LASBRA-LARNEDA%202013.pdf Fil: Pautassi, Ricardo Marcos. Universidad Nacional de Córdoba; Argentina. Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Drogadicción 2023-03-20T18:12:19Z 2023-03-20T18:12:19Z 2013 conferenceObject http://hdl.handle.net/11086/546703 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso; Electrónico y/o Digital |
| spellingShingle | ADOLESCENT RAT ANXIETY ALCOHOL Pautassi, Ricardo Marcos Individual differences predictive of ethanol-induced reinforcement and ethanol intake during adolescence |
| title | Individual differences predictive of ethanol-induced reinforcement and ethanol intake during adolescence |
| title_full | Individual differences predictive of ethanol-induced reinforcement and ethanol intake during adolescence |
| title_fullStr | Individual differences predictive of ethanol-induced reinforcement and ethanol intake during adolescence |
| title_full_unstemmed | Individual differences predictive of ethanol-induced reinforcement and ethanol intake during adolescence |
| title_short | Individual differences predictive of ethanol-induced reinforcement and ethanol intake during adolescence |
| title_sort | individual differences predictive of ethanol induced reinforcement and ethanol intake during adolescence |
| topic | ADOLESCENT RAT ANXIETY ALCOHOL |
| url | http://hdl.handle.net/11086/546703 |
| work_keys_str_mv | AT pautassiricardomarcos individualdifferencespredictiveofethanolinducedreinforcementandethanolintakeduringadolescence |