Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
Fil: Chierentin, Lucas. Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Ciências Farmacêuticas; Brazil.
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Format: | publishedVersion |
Language: | eng |
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2022
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Online Access: | https://link.springer.com/article/10.1208/s12249-014-0259-8 http://hdl.handle.net/11086/27914 http://dx.doi.org/10.1208/s12249-014-0259-8 |
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author | Chierentin, Lucas Garnero, Claudia Chattah, Ana Karina Delvadia, Poonam Karnes, Thomas Longhi, Marcela Raquel Salgado, Hérida Regina Nunes |
author_facet | Chierentin, Lucas Garnero, Claudia Chattah, Ana Karina Delvadia, Poonam Karnes, Thomas Longhi, Marcela Raquel Salgado, Hérida Regina Nunes |
author_sort | Chierentin, Lucas |
collection | Repositorio Digital Universitario |
description | Fil: Chierentin, Lucas. Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Ciências Farmacêuticas; Brazil. |
format | publishedVersion |
id | rdu-unc.27914 |
institution | Universidad Nacional de Cordoba |
language | eng |
publishDate | 2022 |
record_format | dspace |
spelling | rdu-unc.279142022-10-13T11:07:55Z Influence of β-cyclodextrin on the Properties of Norfloxacin Form A Chierentin, Lucas Garnero, Claudia Chattah, Ana Karina Delvadia, Poonam Karnes, Thomas Longhi, Marcela Raquel Salgado, Hérida Regina Nunes Bioassay Complexation Intrinsic dissolution Norfloxacin β-cyclodextrin Beta-cyclodextrin publishedVersion Fil: Chierentin, Lucas. Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Ciências Farmacêuticas; Brazil. Fil: Garnero, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Garnero, Claudia. Universidad Nacional de Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Chattah, Ana Karina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Fil: Chattah, Ana Karina. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina. Fil: Delvadia, Poonam. Virginia Commonwealth University. Department of Pharmaceutics, School of Pharmacy; United States of America. Fil: Karnes, Thomas. Virginia Commonwealth University. Department of Pharmaceutics, School of Pharmacy; United States of America. Fil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Salgado, Hérida Regina Nunes. Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas; Brazil. Cyclodextrins are able to form host-guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and β-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and β-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with β-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of β-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug. publishedVersion Fil: Chierentin, Lucas. Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Ciências Farmacêuticas; Brazil. Fil: Garnero, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Garnero, Claudia. Universidad Nacional de Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Chattah, Ana Karina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Fil: Chattah, Ana Karina. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina. Fil: Delvadia, Poonam. Virginia Commonwealth University. Department of Pharmaceutics, School of Pharmacy; United States of America. Fil: Karnes, Thomas. Virginia Commonwealth University. Department of Pharmaceutics, School of Pharmacy; United States of America. Fil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Salgado, Hérida Regina Nunes. Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas; Brazil. Química orgánica 2022-08-03T16:00:43Z 2014-12-16 article https://link.springer.com/article/10.1208/s12249-014-0259-8 http://hdl.handle.net/11086/27914 http://dx.doi.org/10.1208/s12249-014-0259-8 http://dx.doi.org/10.1208/s12249-014-0259-8 eng Attribution-NonCommercial-NoDerivatives 4.0 International http://dx.doi.org/10.1208/s12249-014-0259-8 http://creativecommons.org/licenses/by-nc-nd/4.0/ Electrónico y/o Digital ISSN: 1530-9932 |
spellingShingle | Bioassay Complexation Intrinsic dissolution Norfloxacin β-cyclodextrin Beta-cyclodextrin Chierentin, Lucas Garnero, Claudia Chattah, Ana Karina Delvadia, Poonam Karnes, Thomas Longhi, Marcela Raquel Salgado, Hérida Regina Nunes Influence of β-cyclodextrin on the Properties of Norfloxacin Form A |
title | Influence of β-cyclodextrin on the Properties of Norfloxacin Form A |
title_full | Influence of β-cyclodextrin on the Properties of Norfloxacin Form A |
title_fullStr | Influence of β-cyclodextrin on the Properties of Norfloxacin Form A |
title_full_unstemmed | Influence of β-cyclodextrin on the Properties of Norfloxacin Form A |
title_short | Influence of β-cyclodextrin on the Properties of Norfloxacin Form A |
title_sort | influence of β cyclodextrin on the properties of norfloxacin form a |
topic | Bioassay Complexation Intrinsic dissolution Norfloxacin β-cyclodextrin Beta-cyclodextrin |
url | https://link.springer.com/article/10.1208/s12249-014-0259-8 http://hdl.handle.net/11086/27914 http://dx.doi.org/10.1208/s12249-014-0259-8 http://dx.doi.org/10.1208/s12249-014-0259-8 |
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