1H NMR Spectroscopy and MR Imaging with hyperpolarised substances
Fil: Graafen, Dirk. Max Planck Institute for Polymer Research; Germany.
| Main Authors: | , , , , , |
|---|---|
| Format: | bookPart |
| Language: | eng |
| Published: |
Elsevier
2022
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/11086/26309 http://dx.doi.org/10.1016/B978-0-12-800184-4.00004-7 |
| _version_ | 1801215446231285760 |
|---|---|
| author | Graafen, Dirk Neudert, Oliver Buljubasich Gentiletti, Lisandro Franzoni, María Belén Dechent, Jan Falk Münnemann, Kerstin |
| author_facet | Graafen, Dirk Neudert, Oliver Buljubasich Gentiletti, Lisandro Franzoni, María Belén Dechent, Jan Falk Münnemann, Kerstin |
| author_sort | Graafen, Dirk |
| collection | Repositorio Digital Universitario |
| description | Fil: Graafen, Dirk. Max Planck Institute for Polymer Research; Germany. |
| format | bookPart |
| id | rdu-unc.26309 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | rdu-unc.263092024-04-16T14:31:37Z 1H NMR Spectroscopy and MR Imaging with hyperpolarised substances Graafen, Dirk Neudert, Oliver Buljubasich Gentiletti, Lisandro Franzoni, María Belén Dechent, Jan Falk Münnemann, Kerstin PHIP DNP NMR MRI Hyperpolarisation Polarising agents Signal enhancement Singlet states Continuous hyperpolarisation Magnetic resonance imaging Nuclear magnetic resonance Fil: Graafen, Dirk. Max Planck Institute for Polymer Research; Germany. Fil: Ebert, Sandro. Max Planck Institute for Polymer Research; Germany. Fil: Ebert, Sandro. Johannes Gutenberg University Medical Center. Department of Radiology; Germany. Fil: Buljubasich Gentiletti, Lisandro. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Fil: Buljubasich Gentiletti, Lisandro. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Fil: Buljubasich Gentiletti, Lisandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina. Fil: Franzoni, María Belén. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Fil: Franzoni, María Belén. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Fil: Franzoni, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina. Fil: Dechent, Jan Falk. Max Planck Institute for Polymer Research; Germany. Fil: Münnemann, Kerstin. Max Planck Institute for Polymer Research; Germany. Despite their wide applicability in natural sciences, NMR and MRI still suffer from their inherently low sensitivity. This can be overcome by hyperpolarisation techniques, such as parahydrogen-induced polarisation and dynamic nuclear polarisation. Here, we focus on the generation of 1H-hyperpolarised substances with both methods. We especially address the severe lifetime issue of the accomplished 1H hyperpolarisation by demonstrating the production of hyperpolarised liquids in a continuous flow fashion and the storage of hyperpolarisation in slowly relaxing singlet states. Another problem of hyperpolarised proton NMR and MRI is the generation of contrast between a small amount of hyperpolarised molecules and a vast thermal background signal. In this contribution, we show the possibility to use the special signal pattern that is inherent to the hyperpolarisation method to generate excellent MRI contrast which may open up unprecedented opportunities to use the standard MRI nucleus 1H, for example, biomedical applications in future. Fil: Graafen, Dirk. Max Planck Institute for Polymer Research; Germany. Fil: Ebert, Sandro. Max Planck Institute for Polymer Research; Germany. Fil: Ebert, Sandro. Johannes Gutenberg University Medical Center. Department of Radiology; Germany. Fil: Buljubasich Gentiletti, Lisandro. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Fil: Buljubasich Gentiletti, Lisandro. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Fil: Buljubasich Gentiletti, Lisandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina. Fil: Franzoni, María Belén. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Fil: Franzoni, María Belén. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Fil: Franzoni, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina. Fil: Dechent, Jan Falk. Max Planck Institute for Polymer Research; Germany. Fil: Münnemann, Kerstin. Max Planck Institute for Polymer Research; Germany. Física Atómica, Molecular y Química (física de átomos y moléculas incluyendo colisión, interacción con radiación, resonancia magnética, Moessbauer Efecto.) 2022-06-14T17:06:30Z 2022-06-14T17:06:30Z 2014 bookPart http://hdl.handle.net/11086/26309 http://dx.doi.org/10.1016/B978-0-12-800184-4.00004-7 http://dx.doi.org/10.1016/B978-0-12-800184-4.00004-7 eng Attribution-NonCommercial-NoDerivatives 4.0 International restrictedAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Impreso Elsevier ISSN: 0066-4103 ISBN: 978-0-12-800184-4 |
| spellingShingle | PHIP DNP NMR MRI Hyperpolarisation Polarising agents Signal enhancement Singlet states Continuous hyperpolarisation Magnetic resonance imaging Nuclear magnetic resonance Graafen, Dirk Neudert, Oliver Buljubasich Gentiletti, Lisandro Franzoni, María Belén Dechent, Jan Falk Münnemann, Kerstin 1H NMR Spectroscopy and MR Imaging with hyperpolarised substances |
| title | 1H NMR Spectroscopy and MR Imaging with hyperpolarised substances |
| title_full | 1H NMR Spectroscopy and MR Imaging with hyperpolarised substances |
| title_fullStr | 1H NMR Spectroscopy and MR Imaging with hyperpolarised substances |
| title_full_unstemmed | 1H NMR Spectroscopy and MR Imaging with hyperpolarised substances |
| title_short | 1H NMR Spectroscopy and MR Imaging with hyperpolarised substances |
| title_sort | 1h nmr spectroscopy and mr imaging with hyperpolarised substances |
| topic | PHIP DNP NMR MRI Hyperpolarisation Polarising agents Signal enhancement Singlet states Continuous hyperpolarisation Magnetic resonance imaging Nuclear magnetic resonance |
| url | http://hdl.handle.net/11086/26309 http://dx.doi.org/10.1016/B978-0-12-800184-4.00004-7 http://dx.doi.org/10.1016/B978-0-12-800184-4.00004-7 |
| work_keys_str_mv | AT graafendirk 1hnmrspectroscopyandmrimagingwithhyperpolarisedsubstances AT neudertoliver 1hnmrspectroscopyandmrimagingwithhyperpolarisedsubstances AT buljubasichgentilettilisandro 1hnmrspectroscopyandmrimagingwithhyperpolarisedsubstances AT franzonimariabelen 1hnmrspectroscopyandmrimagingwithhyperpolarisedsubstances AT dechentjanfalk 1hnmrspectroscopyandmrimagingwithhyperpolarisedsubstances AT munnemannkerstin 1hnmrspectroscopyandmrimagingwithhyperpolarisedsubstances |