On stochastic spatial patterns and neuronal polarity
Fil: Menchón, Silvia Adriana. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina.
| Main Authors: | , |
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| Format: | publishedVersion |
| Language: | eng |
| Published: |
2022
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| Online Access: | http://hdl.handle.net/11086/24805 http://dx.doi.org/10.1140/epjb/e2014-50267-1 |
| _version_ | 1801214541099433984 |
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| author | Menchón, Silvia Adriana Wio, Horacio Sergio |
| author_facet | Menchón, Silvia Adriana Wio, Horacio Sergio |
| author_sort | Menchón, Silvia Adriana |
| collection | Repositorio Digital Universitario |
| description | Fil: Menchón, Silvia Adriana. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. |
| format | publishedVersion |
| id | rdu-unc.24805 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2022 |
| record_format | dspace |
| spelling | rdu-unc.248052022-10-13T11:07:28Z On stochastic spatial patterns and neuronal polarity Menchón, Silvia Adriana Wio, Horacio Sergio Modelos estocásticos espaciales Biofísica Stochastic spatial patterns Biophysics publishedVersion Fil: Menchón, Silvia Adriana. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Fil: Menchón, Silvia Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina. Fil: Menchón, Silvia Adriana. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Fil: Wio, Horacio Sergio. Universidad de Cantabria. Instituto de Física de Cantabria; España. Fil: Wio, Horacio Sergio. Consejo Superior de Investigaciones Científicas. Instituto de Física de Cantabria; España. Polarization refers to asymmetric changes in cellular organization that occur in response to external or internal signals. Although neurons can spontaneously establish and maintain asymmetric distributions of signalling molecules on the plasma membrane, it is not clear how intrinsic noise affects neuronal polarization. In this work we present a stochastic model based on endocytosis, exocytosis and lateral diffusion, to study the effects of low number of molecules, (high noise intensity), on neuronal polarization. Numerical results were obtained by solving the master equation using Gillespie?s algorithm. Our model suggests that the formation of a single pole of molecular asymmetry is very robust to noise; furthermore, in the presence of noise, neuronal polarization could occur even with reduced feedback strength. publishedVersion Fil: Menchón, Silvia Adriana. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Fil: Menchón, Silvia Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina. Fil: Menchón, Silvia Adriana. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Fil: Wio, Horacio Sergio. Universidad de Cantabria. Instituto de Física de Cantabria; España. Fil: Wio, Horacio Sergio. Consejo Superior de Investigaciones Científicas. Instituto de Física de Cantabria; España. Otras ciencias físicas 2022-05-11T19:31:09Z 2014 article http://hdl.handle.net/11086/24805 http://dx.doi.org/10.1140/epjb/e2014-50267-1 eng http://www.springer.com/materials/journal/10051 Attribution-NonCommercial-NoDerivatives 4.0 International restrictedAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Impreso; Electrónico y/o Digital ISSN: 1434-6028 |
| spellingShingle | Modelos estocásticos espaciales Biofísica Stochastic spatial patterns Biophysics Menchón, Silvia Adriana Wio, Horacio Sergio On stochastic spatial patterns and neuronal polarity |
| title | On stochastic spatial patterns and neuronal polarity |
| title_full | On stochastic spatial patterns and neuronal polarity |
| title_fullStr | On stochastic spatial patterns and neuronal polarity |
| title_full_unstemmed | On stochastic spatial patterns and neuronal polarity |
| title_short | On stochastic spatial patterns and neuronal polarity |
| title_sort | on stochastic spatial patterns and neuronal polarity |
| topic | Modelos estocásticos espaciales Biofísica Stochastic spatial patterns Biophysics |
| url | http://hdl.handle.net/11086/24805 http://dx.doi.org/10.1140/epjb/e2014-50267-1 |
| work_keys_str_mv | AT menchonsilviaadriana onstochasticspatialpatternsandneuronalpolarity AT wiohoraciosergio onstochasticspatialpatternsandneuronalpolarity |