Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions
Fil: Gilligan, Gerardo Marcelo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.
| Main Authors: | , , , , |
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| Format: | conferenceObject |
| Language: | eng |
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2022
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| Online Access: | http://hdl.handle.net/11086/23671 |
| _version_ | 1806011958892167168 |
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| author | Gilligan, Gerardo Marcelo Piemonte, Eduardo David Panico, René Luis Di Tada, Cecilia E. Brunotto, Mabel |
| author_facet | Gilligan, Gerardo Marcelo Piemonte, Eduardo David Panico, René Luis Di Tada, Cecilia E. Brunotto, Mabel |
| author_sort | Gilligan, Gerardo Marcelo |
| collection | Repositorio Digital Universitario |
| description | Fil: Gilligan, Gerardo Marcelo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. |
| format | conferenceObject |
| id | rdu-unc.23671 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2022 |
| record_format | dspace |
| spelling | rdu-unc.236712024-07-02T18:52:24Z Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions Gilligan, Gerardo Marcelo Piemonte, Eduardo David Panico, René Luis Di Tada, Cecilia E. Brunotto, Mabel Cáncer bucal Inflamación endodóntica Inmunohistoquímica Fil: Gilligan, Gerardo Marcelo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. Fil: Piemonte, Eduardo David. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. Fil: Panico, René Luis. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. Fil: Di Tada, Cecilia E. Fundación para el progreso de la Medicina; Argentina. Fil: Di Tada, Cecilia E.. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica; Argentina. Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. Previous works of our team had shown clinical data which suggest that Chronic Mechanical Irritation (CMI) could be a risk factor for Oral Cancer (OC). However, there are no known patterns of biomarkers in CMI indicative of cellular malignancy. The aim of this study was to identify a biomarker pattern of differentiation (Ck19) and cell proliferation (Ki67) in CMI-associated lesions, similar to those observed in OC. Methods: a Cross-sectional study of adult patients (n = 61), both sexes, with lesions associated with CMI according to the Piemonte et al criteria. CK19 and Ki67 Immunohistochemistry were carried out in biopsies of both types of lesions and the patterns were described according to previous publications of Safadi and Argyris. The present study was approved by Ethics Committee of the College of Dentistry, Universidad Nacional de Cordoba. Results: Ki67 overexpression and a CK19 focal pattern with strong intensity in basal and parabasal cells were observed in CMI lesions, similar to that observed in OC. Conclusion: there is no scientific literature on biomarker patterns of Oral CMI. Therefore, the described pattern, particularly Ck19, is novel and could be indicative of the relationship between the presence of CMI and oral carcinogenesis. Fil: Gilligan, Gerardo Marcelo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. Fil: Piemonte, Eduardo David. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. Fil: Panico, René Luis. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. Fil: Di Tada, Cecilia E. Fundación para el progreso de la Medicina; Argentina. Fil: Di Tada, Cecilia E.. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica; Argentina. Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. Otras Ciencias de la Salud 2022-04-06T14:03:44Z 2022-04-06T14:03:44Z 2018 conferenceObject http://hdl.handle.net/11086/23671 eng Attribution-NonCommercial-ShareAlike 4.0 International https://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso |
| spellingShingle | Cáncer bucal Inflamación endodóntica Inmunohistoquímica Gilligan, Gerardo Marcelo Piemonte, Eduardo David Panico, René Luis Di Tada, Cecilia E. Brunotto, Mabel Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions |
| title | Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions |
| title_full | Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions |
| title_fullStr | Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions |
| title_full_unstemmed | Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions |
| title_short | Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions |
| title_sort | oral carcinogenesis biomarkers in oral chronic mechanical irritation associated lesions |
| topic | Cáncer bucal Inflamación endodóntica Inmunohistoquímica |
| url | http://hdl.handle.net/11086/23671 |
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