Bisphosphonates study on effect of implant-bone interface
Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
| Main Authors: | , , , , |
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| Format: | conferenceObject |
| Language: | eng |
| Published: |
2021
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| Subjects: | |
| Online Access: | http://hdl.handle.net/11086/21622 |
| _version_ | 1806012175929573376 |
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| author | Brunengo, Ignacio Virga, María Carolina Aguzzi, Alejandra Sosa, Federico Marion, Gustavo Carlos |
| author_facet | Brunengo, Ignacio Virga, María Carolina Aguzzi, Alejandra Sosa, Federico Marion, Gustavo Carlos |
| author_sort | Brunengo, Ignacio |
| collection | Repositorio Digital Universitario |
| description | Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina. |
| format | conferenceObject |
| id | rdu-unc.21622 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2021 |
| record_format | dspace |
| spelling | rdu-unc.216222024-07-02T13:08:49Z Bisphosphonates study on effect of implant-bone interface Brunengo, Ignacio Virga, María Carolina Aguzzi, Alejandra Sosa, Federico Marion, Gustavo Carlos Implantación dental Implantes dentales Alendronato Difosfonatos Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina. Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina. Fil: Aguzzi, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica A; Argentina. Fil: Sosa, Federico. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina. Fil: Marion, Gustavo Carlos. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Prostodoncia III A; Argentina. Introduction: The success of any dental implant depends on a number of parameters including general health conditions, biocompatibility of implant materials, the nature of the surface of the microscopic and macroscopic implant, the surgical procedure and the quality and quantity of bone maxilla. Objective: to evaluate the alkaline phosphatase (AP) levels to analyze the therapeutic response to treatment with bisphosphonates administered subcutaneously in experimental animals. Materials and Methods: The pharmaceutical formulations were prepared with a dosage for Alendronate (AL) of 0.5 mg / kg weight, and pamidronate (PA) of 0.6 mg / Kg . Control (C) was saline. The effect was evaluated in normal male Wistar rats, which were divided into three groups, one control and two problems. We designed a class IV titanium microimplant dimensions 1 mm diameter by 2 mm to place in rat tibia after a drilling operation with strawberry No.6 manual rotation. AP in blood was measured to analyze bone level changes. Comparison of the data was performed by analysis of variance of two criteria (treatments and treatment times: 0, 15, 30, 60 and 90 days). Differences were considered significant if p <0.05. Results: The average value obtained in pubertal rats was 1425 IU / I, and in normal adult rats taken as a parameter for estimating the bone marker normal values in rats was 51.03 IU / l. The data showed that the experimental groups at 15 days 1.37 higher PA than AL; 30 days PA is 1.12 higher than Al, at 60 days 1, 14 and 90 days increased 1.07 higher. Conclusions: The experimental model healthy male rats subcutaneously weekly treatment with AL and PA for 12 weeks resulted in significant variations in mineral concentrations in blood, revealing an inhibitory action on osteoclast activity by the drugs studied . Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina. Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina. Fil: Aguzzi, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica A; Argentina. Fil: Sosa, Federico. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina. Fil: Marion, Gustavo Carlos. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Prostodoncia III A; Argentina. Otras Ciencias Médicas 2021-11-18T14:54:55Z 2021-11-18T14:54:55Z 2014 conferenceObject http://hdl.handle.net/11086/21622 eng Attribution-NonCommercial-ShareAlike 4.0 International https://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso |
| spellingShingle | Implantación dental Implantes dentales Alendronato Difosfonatos Brunengo, Ignacio Virga, María Carolina Aguzzi, Alejandra Sosa, Federico Marion, Gustavo Carlos Bisphosphonates study on effect of implant-bone interface |
| title | Bisphosphonates study on effect of implant-bone interface |
| title_full | Bisphosphonates study on effect of implant-bone interface |
| title_fullStr | Bisphosphonates study on effect of implant-bone interface |
| title_full_unstemmed | Bisphosphonates study on effect of implant-bone interface |
| title_short | Bisphosphonates study on effect of implant-bone interface |
| title_sort | bisphosphonates study on effect of implant bone interface |
| topic | Implantación dental Implantes dentales Alendronato Difosfonatos |
| url | http://hdl.handle.net/11086/21622 |
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