Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
| Main Authors: | , , , , , , |
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| Format: | conferenceObject |
| Language: | eng |
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2021
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| Online Access: | http://hdl.handle.net/11086/21543 |
| _version_ | 1801212915873742848 |
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| author | Interlandi, Victoria Fontanetti, Pablo Alejandro Ponce, Rubén Hugo Tirao, Germán Alfredo Rigalli, Alfredo Gallará, Raquel Vivian Centeno, Viviana Andrea |
| author_facet | Interlandi, Victoria Fontanetti, Pablo Alejandro Ponce, Rubén Hugo Tirao, Germán Alfredo Rigalli, Alfredo Gallará, Raquel Vivian Centeno, Viviana Andrea |
| author_sort | Interlandi, Victoria |
| collection | Repositorio Digital Universitario |
| description | Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. |
| format | conferenceObject |
| id | rdu-unc.21543 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2021 |
| record_format | dspace |
| spelling | rdu-unc.215432021-11-17T09:37:31Z Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats Interlandi, Victoria Fontanetti, Pablo Alejandro Ponce, Rubén Hugo Tirao, Germán Alfredo Rigalli, Alfredo Gallará, Raquel Vivian Centeno, Viviana Andrea Fluoruros Fluorosis dental Exposición materna Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Introducción a la Química y Física Biológicas A; Argentina. Fil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Fil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; Argentina. Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Fil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Controversy exists over the maternal–fetal passage of fluoride (F-). This work sought to explore different aspects of F-metabolism during pregnancy and lactation in mothers and offspring. The specific aim was to study F-accumulation in bones and teeth and growth morphometric parameters in the offspring of mothers exposed to high levels of F- in drinking water. Pups aged 10-, 15- and 21-day-old from 2 groups of mothers were used: a) control mothers (0.3 mg/L F-); b) treated mothers (50 mg/L F-). The treatment was performed during the period of pregnancy and lactation. All animals were euthanized and the upper and lower jaw and tibia of mothers were removed for the determination of F-. Incisor diameter, mandibular growth and tibia length were determined on RX digitalized images. Results were analyzed by Student t test. Accumulated F-content was significantly higher in the jaws (p b 0.05), incisor (p b 0.01) and tibia (p b 0.05) of mothers exposed to F- compared to control. In 10- and 15-day-old pups born to treated mothers, F-content in jaws did not differ from the control. However, in 21-day-old pups, accumulated F- was higher (p b 0.05). No differences were found in Fcontent or growth parameters in tibia of the offspring in all studied groups. Lower incisor diameter was lower in 21-day-old pups born to mothers exposed 50 mg/L F-compared to their controls (p b 0.01). The results suggest that F-accumulation in calcified tissues of the offspring is lower than in maternal tissues. The passage of F- mother-offspring could occur through milk during lactation. Further studies would help to elucidate the mechanism of this process. Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Introducción a la Química y Física Biológicas A; Argentina. Fil: Ponce, Rubén Hugo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Fil: Tirao, Germán Alfredo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; Argentina. Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Fil: Gallará, Raquel Vivian. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Bioquímica y Biología Molecular (ídem 1.6.3) 2021-11-16T14:44:19Z 2021-11-16T14:44:19Z 2016 conferenceObject 8756-3282 http://hdl.handle.net/11086/21543 eng Attribution-NonCommercial-ShareAlike 4.0 International https://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso |
| spellingShingle | Fluoruros Fluorosis dental Exposición materna Interlandi, Victoria Fontanetti, Pablo Alejandro Ponce, Rubén Hugo Tirao, Germán Alfredo Rigalli, Alfredo Gallará, Raquel Vivian Centeno, Viviana Andrea Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats |
| title | Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats |
| title_full | Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats |
| title_fullStr | Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats |
| title_full_unstemmed | Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats |
| title_short | Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats |
| title_sort | effect of pre and post natal exposure to fluoride on fluorosis indicators in offspring of rats |
| topic | Fluoruros Fluorosis dental Exposición materna |
| url | http://hdl.handle.net/11086/21543 |
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