Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016
Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.
| Main Authors: | , , , , |
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| Format: | dataSet |
| Language: | spa |
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2020
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| Online Access: | https://doi.org/10.6084/m9.figshare.7117907.v1 http://hdl.handle.net/11086/17030 |
| _version_ | 1801211375531327488 |
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| author | Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel |
| author_facet | Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel |
| author_sort | Kembro, Jackeline Melissa |
| collection | Repositorio Digital Universitario |
| description | Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. |
| format | dataSet |
| id | rdu-unc.17030 |
| institution | Universidad Nacional de Cordoba |
| language | spa |
| publishDate | 2020 |
| record_format | dspace |
| spelling | rdu-unc.170302020-12-09T05:09:28Z Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016 Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel Animal Physiology - Biophysics Animal Physiology - Systems Biophysics Mitochondria Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress enzymes Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Cortassa, Sonia. National Institutes of Health. NIH · NIA Intramural Research Program; Estados Unidos. Lloyd, David. Cardiff University. School of Biosciences 1; Inglaterra. Sollot, Steven. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. Aon, Miguel. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. Analytical methods. Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integration of model equations. To allow transient states to vanish, the system was computed during a time lapse of 2 e8 ms.All studies were performed using the parameter setting optimized in our previous work (Kembro et al. 2013. Biophys J 104(2):332-343; Kembro et al., 2014. Front Physiol 5:257), with ADPm = 0.01mM, i.e. consistent with energized mitochondria under state 4 respiration. The two .txt file represents the time reference and the time series of variables output of the model, in order from left to right column: 1) Mitochondrial Ca+;2) Mitochondrial ADP; 3) Membrane potential; 4)Mitocondrial NADH; 5) Mitochondrial H+; 6) Mitochondrial Phosfate, Pi; 7) Isocitrate; 8) a-ketoglutarate; 9) Succinyl CoA; 10) Succinate; 11) Fumarate; 12) Malate; 13) Oxaloacetate; 14) NADPH; 15) Mitochondrial superoxide; 16) Extramitochondrial superoxide; 17) Mitochondrial hydrogen peroxide; 18) Extramitochondrial hydrogen peroxide; 19) Mitochondrial GSH; 20) Extramitochondrial GSH; 21)Mitochondrial GSSG; 22) Mitochondrial TrxSH2; 23) ExtramitochondrialTrxSH; 24)Mitochondrial PSSGm; 25) Extramitochondrial PSSG. Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Cortassa, Sonia. National Institutes of Health. NIH · NIA Intramural Research Program; Estados Unidos. Lloyd, David. Cardiff University. School of Biosciences 1; Inglaterra. Sollot, Steven. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. Aon, Miguel. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. 2020-12-07T13:40:19Z 2020-12-07T13:40:19Z 2018-09-26 dataSet Kembro, Jackelyn Melissa; Cortassa, Sonia; Lloyd, David; Sollott, Steven; Aon, Miguel (2018): Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016 mM. figshare. Dataset. https://doi.org/10.6084/m9.figshare.7117907.v1 https://doi.org/10.6084/m9.figshare.7117907.v1 http://hdl.handle.net/11086/17030 spa Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| spellingShingle | Animal Physiology - Biophysics Animal Physiology - Systems Biophysics Mitochondria Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress enzymes Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016 |
| title | Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016 |
| title_full | Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016 |
| title_fullStr | Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016 |
| title_full_unstemmed | Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016 |
| title_short | Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016 |
| title_sort | chaotic fluctuations in mitochondrial function under oxidative stress sod2 concentrations of 0 016 |
| topic | Animal Physiology - Biophysics Animal Physiology - Systems Biophysics Mitochondria Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress enzymes |
| url | https://doi.org/10.6084/m9.figshare.7117907.v1 http://hdl.handle.net/11086/17030 |
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