Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM
Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exacta, Físicas y Naturales. Argentina
| Main Authors: | , , , , |
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| Format: | workingPaper |
| Language: | eng |
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2020
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| Online Access: | https://doi.org/10.6084/m9.figshare.7117808.v1 http://hdl.handle.net/11086/17029 |
| _version_ | 1801212079031451648 |
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| author | Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel |
| author_facet | Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel |
| author_sort | Kembro, Jackeline Melissa |
| collection | Repositorio Digital Universitario |
| description | Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exacta, Físicas y Naturales. Argentina |
| format | workingPaper |
| id | rdu-unc.17029 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2020 |
| record_format | dspace |
| spelling | rdu-unc.170292020-12-07T13:23:18Z Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress factors Oscilaciones Signaling Respiration Superoxide dismutase activity Oxidative stress enzymes Time series Biologia Molecular Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exacta, Físicas y Naturales. Argentina Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Cortassa, Sonia. National Institutes of Health. NIH · NIA Intramural Research Program; Estados Unidos. Lloyd, David. Cardiff University. School of Biosciences 1; Inglaterra. Sollot, Steven. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. Aon, Miguel. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. Analytical methods. Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integration of model equations. To allow transient states to vanish, the system was computed during a time lapse of 2 e8 ms. All studies were performed using the parameter setting optimized in our previous work (Kembro et al. 2013. Biophys J 104(2):332-343; Kembro et al., 2014. Front Physiol 5:257), with ADPm = 0.01mM, i.e. consistent with energized mitochondria under state 4 respiration. The two .txt file represents the time reference and the time series of variables output of the model, in order from left to right column: 1) Mitochondrial Ca+;2) Mitochondrial ADP; 3) Membrane potential; 4)Mitocondrial NADH; 5) Mitochondrial H+; 6) Mitochondrial Phosfate, Pi; 7) Isocitrate; 8) a-ketoglutarate; 9) Succinyl CoA; 10) Succinate; 11) Fumarate; 12) Malate; 13) Oxaloacetate; 14) NADPH; 15) Mitochondrial superoxide; 16) Extramitochondrial superoxide; 17) Mitochondrial hydrogen peroxide; 18) Extramitochondrial hydrogen peroxide; 19) Mitochondrial GSH; 20) Extramitochondrial GSH; 21)Mitochondrial GSSG; 22) Mitochondrial TrxSH2; 23) ExtramitochondrialTrxSH; 24)Mitochondrial PSSGm; 25) Extramitochondrial PSSG. Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exacta, Físicas y Naturales. Argentina Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Cortassa, Sonia. National Institutes of Health. NIH · NIA Intramural Research Program; Estados Unidos. Lloyd, David. Cardiff University. School of Biosciences 1; Inglaterra. Sollot, Steven. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. Aon, Miguel. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. 2020-12-07T13:22:06Z 2020-12-07T13:22:06Z 2018 workingPaper Kembro, Jackelyn Melissa; Cortassa, Sonia; Lloyd, David; Sollott, Steven; Aon, Miguel (2018): Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM. figshare. Dataset https://doi.org/10.6084/m9.figshare.7117808.v1 http://hdl.handle.net/11086/17029 eng Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| spellingShingle | Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress factors Oscilaciones Signaling Respiration Superoxide dismutase activity Oxidative stress enzymes Time series Biologia Molecular Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM |
| title | Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM |
| title_full | Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM |
| title_fullStr | Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM |
| title_full_unstemmed | Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM |
| title_short | Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM |
| title_sort | periodic oscillations in mitochondrial function under oxidative stress sod2 concentrations of 0 013 mm |
| topic | Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress factors Oscilaciones Signaling Respiration Superoxide dismutase activity Oxidative stress enzymes Time series Biologia Molecular |
| url | https://doi.org/10.6084/m9.figshare.7117808.v1 http://hdl.handle.net/11086/17029 |
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