Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM
Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.
| Main Authors: | , , , , |
|---|---|
| Format: | dataSet |
| Language: | eng |
| Published: |
2020
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/11086/16912 |
| _version_ | 1801216341026275328 |
|---|---|
| author | Kembro, Jackelyn Melissa Cortassa, Sonia Lloyd, David Sollot, Steven Aon, Miguel |
| author_facet | Kembro, Jackelyn Melissa Cortassa, Sonia Lloyd, David Sollot, Steven Aon, Miguel |
| author_sort | Kembro, Jackelyn Melissa |
| collection | Repositorio Digital Universitario |
| description | Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. |
| format | dataSet |
| id | rdu-unc.16912 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2020 |
| record_format | dspace |
| spelling | rdu-unc.169122021-04-15T14:29:15Z Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM Kembro, Jackelyn Melissa Cortassa, Sonia Lloyd, David Sollot, Steven Aon, Miguel Animal Physiology - Systems Molecular Biology Superoxide dismutase activity Respiration Oxidative stress effect Oxidative stress enzymes https://purl.org/becyt/ford/4.3 Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Fil: Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Fil: Cortassa, Sonia. National Institutes of Health. NIH · NIA Intramural Research Program; Estados Unidos. Fil: Lloyd, David. Cardiff University. School of Biosciences 1; Inglaterra. Fil: Sollot, Steven. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. Fil: Aon, Miguel. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integration of model equations. To allow transient states to vanish, the system was computed during a time lapse of 2 e8 ms. The solutions were then evaluated with the function deval.m in MATLAB R2017a to obtain a time series with constant sampling frequency at 1ms. All studies were performed using the parameter setting optimized in our previous work (Kembro et al. 2013. Biophys J 104(2):332-343; Kembro et al., 2014. Front Physiol 5:257), with ADPm = 0.01mM, i.e. consistent with energized mitochondria under state 4 respiration. The two .txt file represents the time reference and the time series of variables output of the model, in order from left to right column:1) Mitochondrial Ca+;2) Mitochondrial ADP; 3) Membrane potential; 4)Mitocondrial NADH; 5) Mitochondrial H+; 6) Mitochondrial Phosfate, Pi; 7) Isocitrate; 8) a-ketoglutarate; 9) Succinyl CoA; 10) Succinate; 11) Fumarate; 12) Malate; 13) Oxaloacetate; 14) NADPH; 15) Mitochondrial superoxide; 16) Extramitochondrial superoxide; 17) Mitochondrial hydrogen peroxide; 18) Extramitochondrial hydrogen peroxide; 19) Mitochondrial GSH; 20) Extramitochondrial GSH; 21)Mitochondrial GSSG; 22) Mitochondrial TrxSH2; 23) ExtramitochondrialTrxSH; 24)Mitochondrial PSSGm; 25) Extramitochondrial PSSG Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Fil: Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Fil: Cortassa, Sonia. National Institutes of Health. NIH · NIA Intramural Research Program; Estados Unidos. Fil: Lloyd, David. Cardiff University. School of Biosciences 1; Inglaterra. Fil: Sollot, Steven. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. Fil: Aon, Miguel. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. 2020-11-25T12:41:00Z 2020-11-25T12:41:00Z 2018-09-26 dataSet Kembro, Jackelyn Melissa; Cortassa, Sonia; Lloyd, David; Sollott, Steven; Aon, Miguel (2018): Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM. figshare. Dataset. https://doi.org/10.6084/m9.figshare.7117913.v1 http://hdl.handle.net/11086/16912 eng info:eu-repo/semantics/altIdentifier/doi/10.6084/m9.figshare.1514982.v1 info:eu-repo/semantics/reference/hdl/11086/17030 info:eurepo/semantics/reference/doi/10.6084/m9.figshare.7117913.v1 Atribución-NoComercial-CompartirIgual 4.0 Internacional Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ |
| spellingShingle | Animal Physiology - Systems Molecular Biology Superoxide dismutase activity Respiration Oxidative stress effect Oxidative stress enzymes https://purl.org/becyt/ford/4.3 Kembro, Jackelyn Melissa Cortassa, Sonia Lloyd, David Sollot, Steven Aon, Miguel Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM |
| title | Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM |
| title_full | Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM |
| title_fullStr | Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM |
| title_full_unstemmed | Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM |
| title_short | Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM |
| title_sort | chaotic fluctuations in mitochondrial function under oxidative stress sod2 concentrations of 0 0216733 mm |
| topic | Animal Physiology - Systems Molecular Biology Superoxide dismutase activity Respiration Oxidative stress effect Oxidative stress enzymes https://purl.org/becyt/ford/4.3 |
| url | http://hdl.handle.net/11086/16912 |
| work_keys_str_mv | AT kembrojackelynmelissa chaoticfluctuationsinmitochondrialfunctionunderoxidativestresssod2concentrationsof00216733mm AT cortassasonia chaoticfluctuationsinmitochondrialfunctionunderoxidativestresssod2concentrationsof00216733mm AT lloyddavid chaoticfluctuationsinmitochondrialfunctionunderoxidativestresssod2concentrationsof00216733mm AT sollotsteven chaoticfluctuationsinmitochondrialfunctionunderoxidativestresssod2concentrationsof00216733mm AT aonmiguel chaoticfluctuationsinmitochondrialfunctionunderoxidativestresssod2concentrationsof00216733mm |