Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
Morelatto, Rosana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.
| Main Authors: | , , , , , |
|---|---|
| Format: | publishedVersion |
| Language: | eng |
| Published: |
Acta Odontológica Latinoamericana
2020
|
| Subjects: | |
| Online Access: | http://dx.doi.org/doi:10.4317/medoral.19351 http://hdl.handle.net/11086/15649 |
| _version_ | 1801214904823185408 |
|---|---|
| author | Morelatto, Rosana Itoiz, María-Elina Guiñazu, Natalia Piccini, Daniel Gea, Susana López de Blanc, Silvia |
| author_facet | Morelatto, Rosana Itoiz, María-Elina Guiñazu, Natalia Piccini, Daniel Gea, Susana López de Blanc, Silvia |
| author_sort | Morelatto, Rosana |
| collection | Repositorio Digital Universitario |
| description | Morelatto, Rosana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina. |
| format | publishedVersion |
| id | rdu-unc.15649 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2020 |
| publisher | Acta Odontológica Latinoamericana |
| record_format | dspace |
| spelling | rdu-unc.156492022-06-08T11:23:32Z Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma Morelatto, Rosana Itoiz, María-Elina Guiñazu, Natalia Piccini, Daniel Gea, Susana López de Blanc, Silvia Field cancerization Oral squamous cell carcinoma Nitric Oxide Synthase 2 (NOS2) Malignity markers Cancerización de campo Carcinoma oral de células escamosas Marcadores de malignidad publishedVersion Morelatto, Rosana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina. Itoiz, María-Elina. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Guiñazu, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina. Piccini, Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina. Gea, Susana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina. López de Blanc, Silvia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina. The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. Conclusions: NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes. publishedVersion Morelatto, Rosana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina. Itoiz, María-Elina. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Guiñazu, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina. Piccini, Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina. Gea, Susana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina. López de Blanc, Silvia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina. 2020-07-20T13:03:55Z 2020-07-20T13:03:55Z 2014-05-07 article Morelatto R, Itoiz ME, Guiñazú N, Piccini D, Gea S, López-de Blanc S. Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2014 May 1;19 (3):e242-7. 1698-4447 http://dx.doi.org/doi:10.4317/medoral.19351 http://hdl.handle.net/11086/15649 eng Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ Acta Odontológica Latinoamericana |
| spellingShingle | Field cancerization Oral squamous cell carcinoma Nitric Oxide Synthase 2 (NOS2) Malignity markers Cancerización de campo Carcinoma oral de células escamosas Marcadores de malignidad Morelatto, Rosana Itoiz, María-Elina Guiñazu, Natalia Piccini, Daniel Gea, Susana López de Blanc, Silvia Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma |
| title | Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma |
| title_full | Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma |
| title_fullStr | Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma |
| title_full_unstemmed | Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma |
| title_short | Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma |
| title_sort | nitric oxide synthase 2 nos2 expression in histologically normal margins of oral squamous cell carcinoma |
| topic | Field cancerization Oral squamous cell carcinoma Nitric Oxide Synthase 2 (NOS2) Malignity markers Cancerización de campo Carcinoma oral de células escamosas Marcadores de malignidad |
| url | http://dx.doi.org/doi:10.4317/medoral.19351 http://hdl.handle.net/11086/15649 |
| work_keys_str_mv | AT morelattorosana nitricoxidesynthase2nos2expressioninhistologicallynormalmarginsoforalsquamouscellcarcinoma AT itoizmariaelina nitricoxidesynthase2nos2expressioninhistologicallynormalmarginsoforalsquamouscellcarcinoma AT guinazunatalia nitricoxidesynthase2nos2expressioninhistologicallynormalmarginsoforalsquamouscellcarcinoma AT piccinidaniel nitricoxidesynthase2nos2expressioninhistologicallynormalmarginsoforalsquamouscellcarcinoma AT geasusana nitricoxidesynthase2nos2expressioninhistologicallynormalmarginsoforalsquamouscellcarcinoma AT lopezdeblancsilvia nitricoxidesynthase2nos2expressioninhistologicallynormalmarginsoforalsquamouscellcarcinoma |