EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION
<div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 127.333px; transform: scale(1.01035, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.0640176448823">Previous studies indicate a...
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| Format: | publishedVersion |
| Language: | eng |
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2019
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| Online Access: | http://hdl.handle.net/11086/13466 |
| _version_ | 1801215677313318912 |
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| author | Dadam, F.; Caeiro, X.; Cisternas, C.D.; Macchione, A.F.; Cambiasso, M.J.; Vivas, L. |
| author_facet | Dadam, F.; Caeiro, X.; Cisternas, C.D.; Macchione, A.F.; Cambiasso, M.J.; Vivas, L. |
| author_sort | Dadam, F.; Caeiro, X.; Cisternas, C.D.; Macchione, A.F.; Cambiasso, M.J.; Vivas, L. |
| collection | Repositorio Digital Universitario |
| description | <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 127.333px; transform: scale(1.01035, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.0640176448823">Previous studies indicate a sex chromosome complement (SCC) effect on the Angiotensin</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 194.8px; transform: scale(0.947701, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.3133509856461">II-sexually dimorphic hypertensive and bradycardic baroreflex responses. We sought to evaluate whether SCC may differentially modulate sexually dimorphic induced sodium</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 228.533px; transform: scale(1.01391, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.122684313297">appetite and specific brain activity due to physiological stimulation of the rennin angiotensin</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 164.133px; top: 262.267px; transform: scale(1.03821, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="541.948016151309">system. For this purpose, we used the "four core genotypes" mouse model, in which the</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 296px; transform: scale(1.02057, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="591.9320176409481">effect of gonadal sex and SCC is dissociated, allowing comparisons of sexually dimorphic</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 329.733px; transform: scale(1.03147, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.0640176448823">traits between XX and XY females as well as in XX and XY males. Gonadectomized mice</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 363.467px; transform: scale(1.05091, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="542.2706828275919">were sodium depleted by furosemide (50 mg/kg) and low sodium diet treatment;</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 397.2px; transform: scale(1.02997, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="516.0173487118483"> control groups were administered the vehicle and maintained on normal sodium diet. </div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 219.067px; top: 532.133px; transform: scale(1.05343, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="486.6840145043136">Twenty-one hours later, the mice were divided into two groups: one was submitted to the water/NaCl 2% choice intake test, while the other was perfused and their brains subjected to the Fos-immunoreactivity (Fos-ir) procedure. Sodium depletion, regardless of genetic sex (XX or XY), induced a significantly lower sodium and water intake in females than in males,</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 429.2px; top: 599.6px; transform: scale(1.02563, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="276.92134158623224">confirming the existence in mice of sexual dimorphism in sodium appetite and the organizational involvement of gonadal steroids. Moreover, our results demonstrate a SCC</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 633.333px; transform: scale(0.999959, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="591.9760176422602">effect on induced brain Fos-ir, showing increased brain activity in XX-SCC mice at the</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 667.067px; transform: scale(1.04449, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.2253509830233">paraventricular nucleus, nucleus of the solitary tract and lateral parabrachial nucleus, as</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 700.8px; transform: scale(1.03925, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.3720176540613">well as an XX-SCC augmented effect on sodium-depletion induced brain activity at two</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 734.533px; transform: scale(1.01565, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.1226843132972">circumventricular organs, the subfornical organ and area postrema, nuclei closely involved</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 768.267px; transform: scale(1.00202, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="266.53734127676506">in fluid and blood pressure homeostasis. </div> |
| format | publishedVersion |
| id | rdu-unc.13466 |
| institution | Universidad Nacional de Cordoba |
| language | eng |
| publishDate | 2019 |
| record_format | dspace |
| spelling | rdu-unc.134662022-06-08T20:49:25Z EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION Dadam, F.; Caeiro, X.; Cisternas, C.D.; Macchione, A.F.; Cambiasso, M.J.; Vivas, L. sex chromosome; fore core genotype mouse model; sex differences; sodium appetite publishedVersion <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 127.333px; transform: scale(1.01035, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.0640176448823">Previous studies indicate a sex chromosome complement (SCC) effect on the Angiotensin</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 194.8px; transform: scale(0.947701, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.3133509856461">II-sexually dimorphic hypertensive and bradycardic baroreflex responses. We sought to evaluate whether SCC may differentially modulate sexually dimorphic induced sodium</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 228.533px; transform: scale(1.01391, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.122684313297">appetite and specific brain activity due to physiological stimulation of the rennin angiotensin</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 164.133px; top: 262.267px; transform: scale(1.03821, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="541.948016151309">system. For this purpose, we used the "four core genotypes" mouse model, in which the</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 296px; transform: scale(1.02057, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="591.9320176409481">effect of gonadal sex and SCC is dissociated, allowing comparisons of sexually dimorphic</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 329.733px; transform: scale(1.03147, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.0640176448823">traits between XX and XY females as well as in XX and XY males. Gonadectomized mice</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 363.467px; transform: scale(1.05091, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="542.2706828275919">were sodium depleted by furosemide (50 mg/kg) and low sodium diet treatment;</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 397.2px; transform: scale(1.02997, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="516.0173487118483"> control groups were administered the vehicle and maintained on normal sodium diet. </div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 219.067px; top: 532.133px; transform: scale(1.05343, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="486.6840145043136">Twenty-one hours later, the mice were divided into two groups: one was submitted to the water/NaCl 2% choice intake test, while the other was perfused and their brains subjected to the Fos-immunoreactivity (Fos-ir) procedure. Sodium depletion, regardless of genetic sex (XX or XY), induced a significantly lower sodium and water intake in females than in males,</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 429.2px; top: 599.6px; transform: scale(1.02563, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="276.92134158623224">confirming the existence in mice of sexual dimorphism in sodium appetite and the organizational involvement of gonadal steroids. Moreover, our results demonstrate a SCC</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 633.333px; transform: scale(0.999959, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="591.9760176422602">effect on induced brain Fos-ir, showing increased brain activity in XX-SCC mice at the</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 667.067px; transform: scale(1.04449, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.2253509830233">paraventricular nucleus, nucleus of the solitary tract and lateral parabrachial nucleus, as</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 700.8px; transform: scale(1.03925, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.3720176540613">well as an XX-SCC augmented effect on sodium-depletion induced brain activity at two</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 734.533px; transform: scale(1.01565, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.1226843132972">circumventricular organs, the subfornical organ and area postrema, nuclei closely involved</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 768.267px; transform: scale(1.00202, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="266.53734127676506">in fluid and blood pressure homeostasis. </div> publishedVersion Fisiología (incluye Citología) 2019-10-29T16:05:45Z 2019-10-29T16:05:45Z 2013 article http://hdl.handle.net/11086/13466 eng Attribution-NonCommercial-ShareAlike 4.0 International https://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso |
| spellingShingle | sex chromosome; fore core genotype mouse model; sex differences; sodium appetite Dadam, F.; Caeiro, X.; Cisternas, C.D.; Macchione, A.F.; Cambiasso, M.J.; Vivas, L. EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION |
| title | EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION |
| title_full | EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION |
| title_fullStr | EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION |
| title_full_unstemmed | EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION |
| title_short | EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION |
| title_sort | effect of sex chromosome complement on sodium appetite and fos immunoreactivity induced by sodium depletion |
| topic | sex chromosome; fore core genotype mouse model; sex differences; sodium appetite |
| url | http://hdl.handle.net/11086/13466 |
| work_keys_str_mv | AT dadamfcaeiroxcisternascdmacchioneafcambiassomjvivasl effectofsexchromosomecomplementonsodiumappetiteandfosimmunoreactivityinducedbysodiumdepletion |