Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
Rats exposed to adolescent isolation (AA) show neurological and behavioral disorders into adulthood, many of them related to changes in response to appetitive reinforcers. Previous studies showed an increase of consummatory Successive Positive Contrast(cSPC, i.e., increased consumption of 32% sugar...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | spa |
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Universidad Nacional de Córdoba
2015
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| Online Access: | https://revistas.unc.edu.ar/index.php/racc/article/view/9482 |
| _version_ | 1811171518161354752 |
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| author | Cuenya, Lucas Serafini, Matías Mustaca, Alba Kamenetzky, Giselle |
| author_facet | Cuenya, Lucas Serafini, Matías Mustaca, Alba Kamenetzky, Giselle |
| author_sort | Cuenya, Lucas |
| collection | Portal de Revistas |
| description | Rats exposed to adolescent isolation (AA) show neurological and behavioral disorders into adulthood, many of them related to changes in response to appetitive reinforcers. Previous studies showed an increase of consummatory Successive Positive Contrast(cSPC, i.e., increased consumption of 32% sugar solution, 24 hours after having access to 4% solution) in rats exposed to AA, in comparison to animals without AA. This study aim at evaluating whether this effect is associated with dopaminergic hyperactivity. Haloperidol (0.1 mg / kg, i.p.) was administered before animals with AA were exposed to the presentation of the increased solution (4% to 32%), while saline was administered to the control group. cSPC effect was not observed in animals receiving haloperidol, while a one trial positive contrast was expressed in animals receiving saline. These results confirm the proposed hypothesis. Although the results are promising, further experiments are needed to determine more precisely the neurochemical correlate of increased cSPC in animals with AA. |
| format | Online |
| id | oai:ojs.revistas.unc.edu.ar:article-9482 |
| institution | Universidad Nacional de Cordoba |
| language | spa |
| publishDate | 2015 |
| publisher | Universidad Nacional de Córdoba |
| record_format | ojs |
| spelling | oai:ojs.revistas.unc.edu.ar:article-94822019-05-27T19:14:54Z Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation Efecto del haloperidol sobre el contraste sucesivo positivo consumatorio en ratas adultas con aislamiento adolescente Cuenya, Lucas Serafini, Matías Mustaca, Alba Kamenetzky, Giselle adolescent isolation positive contrast haloperidol dopamine rat aislamiento adolescente contraste positivo haloperidol dopamina rata Rats exposed to adolescent isolation (AA) show neurological and behavioral disorders into adulthood, many of them related to changes in response to appetitive reinforcers. Previous studies showed an increase of consummatory Successive Positive Contrast(cSPC, i.e., increased consumption of 32% sugar solution, 24 hours after having access to 4% solution) in rats exposed to AA, in comparison to animals without AA. This study aim at evaluating whether this effect is associated with dopaminergic hyperactivity. Haloperidol (0.1 mg / kg, i.p.) was administered before animals with AA were exposed to the presentation of the increased solution (4% to 32%), while saline was administered to the control group. cSPC effect was not observed in animals receiving haloperidol, while a one trial positive contrast was expressed in animals receiving saline. These results confirm the proposed hypothesis. Although the results are promising, further experiments are needed to determine more precisely the neurochemical correlate of increased cSPC in animals with AA. Las ratas expuestas a aislamiento adolescente (AA) muestran alteraciones neurológicas y conductuales en la adultez, muchas de ellas relacionadas con cambios en la respuesta ante reforzadores apetitivos. En estudios previos las ratas con AA mostraron un incremento del Contraste Sucesivo Positivo consumatorio(CSPc, i.e, mayor consumo de una solución azucarada al 32%, 24 hs después de tener acceso a una solución al 4%), respecto de animales sin AA. El objetivo de este estudio fue evaluar si este efecto está asociado a la hiperactividad dopaminérgica. Se administró haloperidol a animales con AA (0.1 mg/kg, i.p.) antes de los ensayos de incremento del refuerzo y salina a un grupo control. No se halló CSPc en los animales que recibieron haloperidol, mientras que en los sujetos con salina se observó en un ensayo. Si bien los resultados apoyan la hipótesis propuesta, es necesario realizar futuros experimentos para determinar con mayor precisión el correlato neuroquímico del incremento de CSPc en animales con AA. Universidad Nacional de Córdoba 2015-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Experimental application/pdf application/msword https://revistas.unc.edu.ar/index.php/racc/article/view/9482 10.32348/1852.4206.v7.n2.9482 Argentinean Journal of Behavioral Sciences; Vol. 7 No. 2 (2015): Revista Argentina de Ciencias del Comportamiento; 30-37 Revista Argentina de Ciencias del Comportamiento; Vol. 7 Núm. 2 (2015): Revista Argentina de Ciencias del Comportamiento; 30-37 1852-4206 10.32348/1852.4206.v7.n2 spa https://revistas.unc.edu.ar/index.php/racc/article/view/9482/Cuenya%20et%20alpp.30-37 https://revistas.unc.edu.ar/index.php/racc/article/view/9482/25378 Derechos de autor 2015 Lucas Cuenya, Matías Serafini, Alba Mustaca, Giselle Kamenetzky |
| spellingShingle | adolescent isolation positive contrast haloperidol dopamine rat aislamiento adolescente contraste positivo haloperidol dopamina rata Cuenya, Lucas Serafini, Matías Mustaca, Alba Kamenetzky, Giselle Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation |
| title | Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation |
| title_alt | Efecto del haloperidol sobre el contraste sucesivo positivo consumatorio en ratas adultas con aislamiento adolescente |
| title_full | Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation |
| title_fullStr | Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation |
| title_full_unstemmed | Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation |
| title_short | Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation |
| title_sort | effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation |
| topic | adolescent isolation positive contrast haloperidol dopamine rat aislamiento adolescente contraste positivo haloperidol dopamina rata |
| topic_facet | adolescent isolation positive contrast haloperidol dopamine rat aislamiento adolescente contraste positivo haloperidol dopamina rata |
| url | https://revistas.unc.edu.ar/index.php/racc/article/view/9482 |
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