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SUMMARY: Arsenic (As) is an environmental toxic widely distributed worldwide. It is found as a food and water pollutant in several countries, including Argentina. Organs and tissues that constitute the immune system are targets of its deleterious effects; thus, the changes that occur after exposure...
SUMMARY: Arsenic (As) is an environmental toxic widely distributed worldwide. It is found as a food and water pollutant in several countries, including Argentina. Organs and tissues that constitute the immune system are targets of its deleterious effects; thus, the changes that occur after exposure to As are related to an impaired immune response. In this sense, it has been reported that Lantana grisebachii Stuck. (LG), Aspidosperma quebracho-blanco Schltdl. (AQB) and Ilex paraguariensis A. St.-Hil. (IP) have antiinflammatory and antioxidant properties; thus, the aim of this thesis was to establish the xenohormetic capacity of the aqueous extracts of this plants and their derivatives, against arsenic-induced immunotoxicity. First, the effects of oral consumption (100 mg of dry extract/Kg/day for 30 days) of phytoextracts were tested in Balb/C mice (n≥3) of both sexes, by determining of phenolic compounds and their bioavailability in hemolymphatic tissues, analysis of organic trophism and oxidative stress parameters, such as aqueous and lipid peroxides (HP and LP respectively), superoxide anion (SO) and nitrites in murine spleen, thymus and blood. The data analysis (ANOVA, p<0,05) confirmed that the three extracts were sources of phenolic compounds (IP, LG and AQB in decreasing order), although their bioavailability in hemolymphatic tissues was conditioned by sex, with often higher concentrations in females. Regarding the redox response, LG consumption had a prooxidant effect with unequal induction of reactive oxygen species (ROS) production in males and females. On the other hand, AQB reduced peroxidation in blood and spleen of both sexes, with positive nitrosative regulation in thymus, although the antioxidant effects were not phenol-dependent. Finally, IP exhibited dissimilar effects according to sex, with some antioxidant effects in males, whereas females showed oxidative susceptibility.
Physical Description:
107 h. : gráf., 29 cm. + Tesis digitalizada completa.
