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| LEADER |
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| 001 |
19979 |
| 003 |
AR-CdUCM |
| 005 |
20240315154120.0 |
| 006 |
a|||||r|||| 00| 0 |
| 007 |
ta |
| 008 |
161114b2015 ag ||||| |||| 00| 0 s d |
| 040 |
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|a AR-CdUCM
|c AR-CdUCM
|
| 100 |
1 |
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|a Lucero, Noelia Soledad
|
| 245 |
1 |
|
|a Prevalencia de anticuerpos totales contra el virus de la hepatitis A (VHA) en individuos adultos de la ciudad de Córdoba /
|c Noelia Soledad Lucero.
|
| 260 |
|
|
|a Córdoba RA :
|b [s.n.],
|c 2015
|
| 300 |
|
|
|a 43 h. :
|b il.,
|
| 502 |
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|a Tesis - Maestría en Microbiología con Orientación en Investigación en Salud Humana - Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Secretaría de Graduados en Ciencias de la Salud, 2015
|
| 520 |
3 |
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|b ABSTRACT: Hepatitis A virus (HAV) has shown intermediate endemicity in Argentina, but notification of clinical cases has decreased since the introduction of the vaccine in 2005. However, in recent years the Ministry of Health of Argentina reported a shift in the incidence of cases, being the most affected adolescents and young adults. In Cordoba, no data updated on the prevalence of antibodies in general adult population. So the objective was to provide information on HAV immune status of the adult population of Córdoba city after four years of the official introduction of the vaccine. The prevalence of anti-HAV was determined by EIA in 416 serum samples of people (without prior vaccination) from Córdoba city (sept2009–sept2010). Spline regression models were estimated under generalized additive models. In Córdoba, the global prevalence of anti-HAV was 73.5%. It increased with age (p < 0.0001) and it was associated with the low-income population (OR: 1.14; 95% CI 1.05–1.25). This prevalence decreased in younger age groups, especially in the high-income population. Overall, and across all age groups, 24 times more HAV prevalence was observed in low income population than in the middle – high income population (p < 0.05). Over age groups, these differences are stressed, showing homogeneity only after 45 years (p = 0.473). HAV prevalence among low-income individuals 18-35 years (62-76%) was markedly higher compared to middle-high income population (41-47%) (p < 0.001 ).
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| 520 |
3 |
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|a Hepatitis A virus (HAV) has shown intermediate endemicity in Argentina, but notification of clinical cases has decreased since the introduction of the vaccine in 2005. However, in recent years the Ministry of Health of Argentina reported a shift in the incidence of cases, being the most affected adolescents and young adults. In Cordoba, no data updated on the prevalence of antibodies in general adult population. So the objective was to provide information on HAV immune status of the adult population of Córdoba city after four years of the official introduction of the vaccine. The prevalence of anti-HAV was determined by EIA in 416 serum samples of people (without prior vaccination) from Córdoba city (sept2009–sept2010). Spline regression models were estimated under generalized additive models. In Córdoba, the global prevalence of anti-HAV was 73.5%. It increased with age (p < 0.0001) and it was associated with the low-income population (OR: 1.14; 95% CI 1.05–1.25). This prevalence decreased in younger age groups, especially in the high-income population. Overall, and across all age groups, 24 times more HAV prevalence was observed in low income population than in the middle – high income population (p < 0.05). Over age groups, these differences are stressed, showing homogeneity only after 45 years (p = 0.473). HAV prevalence among low-income individuals 18-35 years (62-76%) was markedly higher compared to middle-high income population (41-47%) (p < 0.001 ). In conclusion, as a consequence of a decrease in HAV circulation due to improvements in immunization, socio-economic and hygienic conditions, young adults are becoming increasingly susceptible to HAV infections. Considering that in the same period, environmental monitoring demonstrated that HAV circulates in the local population; health care systems should consider the implementation of preventive measures for susceptible adults in order to reduce the risk of HAV infection.
|
| 650 |
1 |
2 |
|a Virus de la Hepatitis A
|
| 650 |
1 |
2 |
|a Seroprevalencia de VIH
|
| 650 |
1 |
2 |
|a Estudios Seroepidemiológicos
|
| 650 |
1 |
2 |
|a Adulto
|
| 650 |
1 |
2 |
|a Argentina
|x epidemiologia
|
| 650 |
1 |
2 |
|a Anticuerpos de Hepatitis A
|
| 700 |
1 |
|
|a Ré, Viviana Elizabeth
|e dra
|9 2605
|
| 942 |
|
|
|2 NLM
|c MMOISH
|
| 945 |
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|a msp
|d 2016-10-14
|
| 952 |
|
|
|0 0
|1 0
|2 ddc
|4 0
|6 TM_L24_2015_000000000000000
|7 0
|9 26255
|a MED
|b MED
|d 2016-11-14
|e donacion
|l 0
|o TM L-24 2015
|p 29114
|r 2016-11-14 00:00:00
|w 2016-11-14
|y MMOISH
|
| 999 |
|
|
|c 19979
|d 19979
|
